Men lose Y-chromosome with age

https://www.sciencedaily.com/releases/2016/05/160523212527.htm
That’s why they die earlier.

Really.
Stop blaming women and ‘sexism’, we aren’t omnipotent gene meddlers.
Also, genetic proof of a male wall. LOL. An explanation to why so many middle-aged men suddenly look like lesbians.

[coughs in Bruce Jenner]

And there’s no way to reverse it, before the snake oil salesmen jump up with a solution that, if it worked, would make them a billionaire.

Nobel winner.

World famous.

Popping pills to get out of laziness is what lefties do.

Bold for the lazy.

Using new tools to analyze genetic variations that accumulate with age, we can help explain how sporadic diseases like cancer or Alzheimer’s manifest,” says first author Jan Dumanski.

One such postzygotic mutation found in the cells of biological males is the loss of the Y chromosome in a degree of blood cells. Loss of Y occurs in up to 17 percent of men and is more likely to be found in older men and men who smoke. This study expands on the idea that loss of Y, already a known risk factor for cancer (10.1038/ng.2966), could be a predictive biomarker for a wider range of poor health outcomes, specifically Alzheimer’s. Why loss of Y can be linked to an increased risk for disease remains unclear, but the authors speculate it has to do with reduced immune system performance.

They should look at age groups of men.

And diet.

IMHO.

The researchers looked at over 3,000 men to ascertain whether there was any predictive association between loss of Y in blood cells and Alzheimer’s disease. The participants came from three long-term studies that could provide regular blood samples: the European Alzheimer’s Disease Initiative, the Uppsala Longitudinal Study of Adult Men, and the Prospective Investigation of the Vasculature in Uppsala Seniors. Across the datasets, those with the highest fraction of blood cells without a Y chromosome were consistently more likely to be diagnosed with Alzheimer’s.

….Really more of an outcome of poor genetic health….

Did you test for aluminium?

Attempt chelation therapy?

Yeah, fuck the easy solution, blame the Y chromosome.

Like women don’t get it.

“Having loss of Y is not 100 percent predictive that you will have either cancer or Alzheimer’s,” Forsberg says, adding that there were men in the study who had the mutation and lived with no symptoms well into their 90s.

Were their fathers older or younger?

If paternal age is a factor in ANYTHING, it’s a risk factor for this.

Male chromosome plus mutation. Come on.

Men think they can fool women but white hairs on a ballsack don’t lie.

“But in the future, loss of Y in blood cells can become a new biomarker for disease risk and perhaps evaluation can make a difference in detecting and treating problems early.”

No shit.

Forsberg, Dumanski, and colleagues will next investigate the effect of loss of Y in larger cohorts and explore in greater detail how it confers risk for specific types of cancers and disease. They also plan to look at the cellular changes caused by loss of Y and how it affects different types of blood cells.The researchers looked at over 3,000 men to ascertain whether there was any predictive association between loss of Y in blood cells and Alzheimer’s disease. The participants came from three long-term studies that could provide regular blood samples: the European Alzheimer’s Disease Initiative, the Uppsala Longitudinal Study of Adult Men, and the Prospective Investigation of the Vasculature in Uppsala Seniors. Across the datasets, those with the highest fraction of blood cells without a Y chromosome were consistently more likely to be diagnosed with Alzheimer’s.”

Should look at heart disease, primary killer of American males.

But that’s none of my business.

If men aged well, they wouldn’t need to be on supplements.
Young men on supplements is just sad, like young women getting plastic surgery.
There’s no room to move. If you can’t be all that young, what are they going to do?
Our society treats aging like cancer, it’s ridiculous Boomer youth cult propaganda to sell them supplements like detox tea and testosterone ball rub. You can’t fool mother nature.

When they actually hit middle-age, they won’t be able to keep up with that crap anyway.
Imagine most of your shallow friends disappearing because you dropped the massive timesink of gym addiction.
The Ken Doll homoerotic gym attention bros look sad after about 40.

Plus bodybuilder types know there are two types of muscle: appearance and strength.
Guess which one they all go for?

The one that instantly converts to stubborn fat if they so much as look at a complex carbohydrate past 30.

The Johnny Bravo look is actually, industry secret, physically weak.

In a fight, any martial artist will tell you the bulk limits their range of motion like a fatty anyway.

All men need is a healthy range of light muscle, which women prefer but don’t require any supplement sales.
Light muscle also provides cognitive benefits with no musculoskeletal downsides, including sag and joint pain.
Bruce Lee could take a Henry Cavill any day of the week.

With the T&A they have a woman’s hourglass in profile, they gay.

At least, appealing to that market…..

Feminine brain, youthful brain

https://www.smithsonianmag.com/smart-news/womens-metabolic-brain-age-around-three-years-younger-mens-180971425/

Predictable.

“New research suggests that women’s brains stay energized well into old age, making their brains appear about three years younger than men’s of the same chronological age.”

Given

https://disenchantedscholar.wordpress.com/2015/11/07/estrogen-boosts-brainpower-actually/

Linked in first:

https://www.pnas.org/content/early/2019/01/29/1815917116

Men didn’t evolve to live long, so it isn’t so much remarkable that women live longer with healthier brains but men,  to be competitive with other men in youth and war, age terribly simply because so few would survive there’s no evolutionary pressure.

Some tough choices ahead for the cooties crowd.

Stick to imaginary phantasms of 20th century masculine superiority solely intended to run up credit debt or actually be healthier.

Here comes the academese:

“Researchers remain uncertain why such metabolic differences exist”

EVOLUTION.

“It’s not that women’s brains seem to age slower than men’s,”

Literally is.
Watch the twist.

“Rather, it seems that women’s brains start off at a younger age when they reach adulthood, and they keep that throughout the remainder of their adulthood, basically buying them a few extra years.”

Not how it works. At all.

It’s like saying you start a race at the finish line, words have meanings.

If they’ve reached adulthood, they’ve reached adulthood. You can’t change the meaning to be quantum. Women mature faster (partially from earlier puberty and slower, longer sum development time because of that) and go on to metabolically age better because testosterone is known to burn out the system.

Gradual puberty + lower T = good for long-term brain health.

aka Not women’s fault. Help your fellow men. Maybe that explains why celibates like Tesla (who, let’s face it, probably didn’t masturbate), who kept their T-levels low as a result, lived longer and stayed lucid. Maybe that’s why monks live longer too, staying sharp. Male chastity has observable benefits.

The autobiographies of genius seem to evidence longer average puberty, too. The sensitive kid who’s a later bloomer?

The Victorians called masturbation self-abuse because the compulsion/addiction would tend to be co-morbid with other mental problems, including depression. How many porn addicts are depressed?

And what do they do to self-soothe because (someone) tells them it’s unanimously ‘good for you’?

Even nuns tend to live longer which does point to lower testosterone being a pre-requisite for a long life, neatly explaining why male levels gradually lower. It isn’t like evolution is picking on men. Aggressive animals have shorter lifespans across species. This is the price of being the protector/provider sex.

https://www.healthline.com/health-news/men-too-much-testosterone-linked-to-shorter-lifespan-112213

“Overall, men with circulating testosterone levels between 9.8 to 15.8 nmol/L range tended to live the longest.”

Men are entitled to know what their healthy levels should be, study them!

Men age faster cognitively, he’s like a magician trying to switch your attention onto women when there’s a medical problem with men.
Assuming they want to live long and prosper.

Like, sorry, if that’s a sexist assumption.

“Previous studies have found that aging women often exhibit stronger reasoning, memory and problem-solving skills than males of the same age. But it’s unclear whether this trend is related specifically to metabolism or to a different aspect of brain function.”

Hormonal interaction.

“This might mean women are a little bit more resilient to certain aspects of brain aging in general, but it could also introduce certain vulnerabilities,”

Lying liar. Not even one example? How can you try to spin a youthful brain as a bad thing?

Women aren’t so much MORE resilient (although oestrogen helps) but men are MORE fragile.

HELP THEM.

“Having a younger brain for longer could make the brain more vulnerable to certain things as well.”

Still no mention of men? This isn’t a woman’s issue, there’s nothing new here as stated, women already perform better as a known overall finding*, he totally ignores what men need because it involves admitting they aren’t the best at something….

These arrogant men are sex traitors. Their ego won’t let them admit men need help. So have fun with higher neurodegeneration risk because one guy won’t admit he’s not #1 at everything.

Men are not the control group, it’s the mean between both groups.

Basic category error and erroneous maths.

Hubris is a deadly sin. Treating male ill-health like it’s normal will literally kill men.

OT but relevant:

If we took men as the control, the shorter male lifespan is not only normal but hinted at being desirable, you don’t want to change the norm, with women being unusually longer-lived (greater distance from norm). Actually, the average is between the groups, again. The difference from the norm is smaller, easier to broach and bring those below it up to speed.

*Because unlike IQ studies, they can’t conveniently ‘exclude’ the left-side of the male bell curve to skew their findings dishonestly. This happens after they sample from middle-class academia pupils largely from suburban populations, a huge bias/filter itself.

Sure, throw other men under the bus and blame women for biology. Sexism both ways!

Reminder:

Adrenochrome and Pituitary posting

I had a spare hour to go through old papers.

It turned into about five and ended with academic papers. Again. This wasn’t enough.

I say to myself “just five more minutes” aaaaand it’s past midnight.

It’s my personal Hell, a nerdy reading spiral. 4,200 words.

You may have seen this gem.
Source:

Of note:
https://www.newspapers.com/image/172018530
Does Christian Europe’s war prove Christianity a failure?
For those who think psyops is new.

No.

It’s a 1914 “if you kill your enemies, they win.”

Final page, 47 of 47.
https://www.newspapers.com/image/172018532
The picture by one Emil Halarek, depicting the victims of Moloch in supposed war.
Why throw that in there? So I include the article.
“A nation is only as formidable as its food supply” something to remember, food security is a main cause of war (food insecurity and an exploding population) otherwise the Communists overthrow their Government because the breadline is too long. If Trump prevents a war with China, I must wonder how they’ll solve their food problem without an expansion into new territory (and Chinese have been buying up large amounts of American farmland for decades).

Screencaps follow: Whole thing

Note: this is about the pineal gland, the pituitary is something different and yes, I am aware. It might be useful upon new information.

Piece by piece. I re-arranged for ease of reading.



This proves there are definite effects of brain tissue on other organisms.

Hey guys, don’t you want your mandated helping of brains to over-grow and be prematurely sent to die snared in barbed wire?

Another source.
https://newspaperarchive.com/richmond-times-dispatch-sep-06-1914-p-28/
Easier to read but I found this second. Sorry.

Final source for this article.
https://chroniclingamerica.loc.gov/lccn/sn85038615/1914-09-06/ed-1/seq-48/

There’s a Factor X but they’re not talking.

https://www.foxnews.com/opinion/factor-x-have-we-finally-found-the-fountain-of-youth

Onward!

Let’s start in reddit tier and move up.

reddit.com/r/nosleep/comments/5rv75f/i_just_learned_the_horrible_impossible_truth/

“He told me about a drug called adrenochrome that could produce a high beyond any other. And unlike those other drugs, there are no ill effects. Quite the contrary; there are substantial benefits from consuming it: greater health, increased vivacity, and a host of other, smaller effects. Combine those with an intense sense of euphoria and you have a substantial demand.”
I wonder if Vlad the Impaler knew this?
It seems to temporarily borrow charisma if the vivacity is true. Who needs Botox?
You can steal youth, it seems. Pied Piper, anyone?
“I recognized the faces sitting around that table.
World leaders. Entertainers. Religious icons. All grinning. All happy. All ready for their injection.”
They fill the icon/idolatry vacuum with their own “stars” and “celebrities” to prevent worthy people gaining attention who might expose them.
Naturally it detours into something about Trump, obvious derailment.

However, lower more details from someone else:
That adrenachrome can be harvested within three minutes of someone passing away, from sudden death rather than old age. It is produced in the adrenal gland, meaning your head needs to be hacked apart in order to harvest. VERY expensive, hence world leaders being able to hit it. First time users aren’t usually told where it came from, they are only allowed to find out AFTER trying it, otherwise it would put them off. After trying it, because it is so clean and supposed to be the very best of the best, users don’t mind how it is harvested as it was just that good.”
I wonder if Christians have more, considering it seems to mimic the health benefits of faith. Would explain the Christian hatred as envy.
“I also heard that like DMT, artificial adrenachrome is found in EVERY plant on the planet, yet in such minuscule amounts that it is not worth or cost effective to go down this route.
This is what I have heard not seen the proof. I have also heard that it is a made up drug, usually from the type of people that can afford to use. Who are also the people who wouldn’t want people finding out.”
“Synthetic epinephrine has been marketed since 1906. No one is murdered for adrenochrome, this is just silly.”
No one needs to be, sure.
“But adrenochrome is really just what’s in an EpiPen.”
Wasn’t Clinton’s assistant toting one of those around?

https://en.wikipedia.org/wiki/Adrenochrome
“Several small-scale studies (involving 15 or fewer test subjects) conducted in the 1950s and 1960s reported that adrenochrome triggered psychotic reactions such as thought disorder, derealization, and euphoria.[2] Researchers Abram Hoffer and Humphry Osmond claimed that adrenochrome is a neurotoxic, psychotomimetic substance and may play a role in schizophrenia and other mental illnesses.[3] In what they called the “adrenochrome hypothesis”,[4] they speculated that megadoses of vitamin C and niacin could cure schizophrenia by reducing brain adrenochrome.[5][6]”

OT Why do they keep chucking niacin in everything? At least half the population isn’t pregnant.

“While the treatment of schizophrenia with such potent anti-oxidants is highly contested in the literature, and adrenochrome is not currently believed to have any psychedelic properties[7] , a number of recently published papers consider Hoffer’s paper a landmark contribution to the notion that impairment of what’s now termed the anti-oxidant defense system (AODS) seems to play a role in schizophrenia.[8] Salim, in 2014, points out “oxidative stress theory is gaining momentum and seems quite pertinent considering the evidenced increased production of ROS and decreased occurrence of antioxidant protection in schizophrenic patients. Genetic studies also have linked polymorphisms in genes of oxidative pathway to schizophrenia.” [9]”

That tells us basically nothing.
Unusual this article is barely there, considering the stuff I dug up!

https://consciousawarenessforall.wordpress.com/2014/11/10/adrenochrome/

What exactly IS adrenochrome? In scientific terms, it is a chemical that is produced in the human body when adrenaline [also known as epinephrine] oxidizes. How is the chemical extracted? A potential victim is terrorized, thus increasing the amount of adrenaline that is flowing through their body. They are then killed and the adrenochrome is collected with a needle and syringe from the base of the back of their neck and spinal column. Once collected, the chemical can be sold on the black market at exorbitant prices.”

Adrenochrome was first discovered in 1936 – 1937 by D. E. GREEN, D. RICHTER and J. BROSTEAUX [though it is sometimes erroneously credited to HUMPHRY OSMOND, ABRAM HOFFER and JOHN SMYTHIES in 1952 – 1954, who came up with the hypothesis linking adrenochrome to schizophrenia]. It was discovered when studying the effects of adrenaline on the human body.”

Nice way to put it.

“……….So, is it possible to create synthetic adrenochrome? As adrenochrome is a product of the oxidation of adrenaline/epinephrine, which can be artificially synthesized via the reaction between catechol and chloroacetyl chloride, there is no reason that it cannot be oxidized to create synthetic adrenochrome”

A medical defense in court wouldn’t stand because it can be synthesized.

This is important.

So why isn’t it publicly available, accessible and widely known of?

http://conspiracy.wikia.com/wiki/Adrenochrome
Hoffer (1957) contested that Adrenochrome appeared naturally in human blood, while Szara et.al. (1958) reported in the exact same journal that there was no Adrenochrome in human blood.”
I wonder why all the interest in stealing youth from young blood?

“It would also explain the need by hospitals and clinics to compulsively take blood from individuals who have experienced severe emotional trauma, despite no true medical need to do so.”
No informed consent. That would explain why it isn’t common knowledge.
Hey, we know your trauma is tragic, but this shitty Legend singer wants to get high off it!
“It is also claimed that adrenochrome-laden human blood is being bought and sold using blood donation charities, such as the Red Cross.”

Red Cross of Q-drop and Clinton Foundation fame.

“Derivatives / Alternatives
Adrenochrome Semicarbazone – Similar, but with noticeably different effects. (Rinkel & Solomon 1957).
Mescalin – Effects similar to adrenaline / adrenochrome. (Smythies 2002)
Neuromelanin – May be related to the synthesis of adrenochrome in the brain.”

Named Hoffer reference is “Hoffer, A (1957). “Adrenochrome in Blood Plasma”. American Journal of Psychiatry 114, 0.”

https://www.erowid.org/experiences/exp.php?ID=51847
“Price:
Most labs sell D,L-Adrenochrome(CAS:56-06-8) at 70 to 100euros for 250mg. But I recently found another chemical supplier selling a product named ‘Adrenochrome’ at 110euros for 50g, the price difference is so huge that I first though it couldn’t be the same compound that other suppliers were selling, but CAS number was 56-06-8 so it was definately the same Adrenochrome.”

Idiot.

Such a price difference seems strange to me, I thought maybe it could be one of the two enantiomers (instead of the D,L form) but this wouldn’t be logical as separating two enantiomers is complicated and therefore one enantiomer alone should be more expensive than the DL form, and certainly not cheaper.”

Processing, yes.

Plus origin would account for pricing.

Idiots.

“Note:
Adrenochrome is quickly oxidised and should be kept away from air, light, humidity and heat. Therefore it is kept in an airtight container which is put in the freezer. Even this way, it will slowly decompose so it should not be kept for too long before use.”

Useful if searching for the stuff on a suspect.

Does the suspect have access to a secured freezer? Why else need that?

“Also, about possible secondary effects of adrenochrome: as it is an haemostatic compound (prevents capillary bleeding during injury) it is not impossible that excessive use would end up causing blood circulation troubles, furthermore some scientists seem to say that adrenochrome is known to cause cardiovascular troubles.
To conclude I would say that this is an uninteresting substance to my opinion, and furthermore it’s possibly a dangerous one.”

Something to look for in addicts.

Cardiac issues.

I went looking for media stories trolling the public with similar themes. Focus on horror and crime, for time’s sake.

Meanwhile
https://www.imdb.com/title/tt0514409/
39th episode, special Illuminati number and Bilderberg members.
http://areyouafraidofthedark.wikia.com/wiki/The_Tale_of_the_Dangerous_Soup
“They had a far more powerful weapon, a statue enchanted with a magic power to induce and feed off their enemies fear.”
That’s a Jewish golem and it’s possessed by a demon. They were supposedly created for real in WW2 to protect synagogues.
“Nonnie, wondering what is has to do with the soup, is that the statue also secrets fear as a green serum elixir. The members of the savage tribe would drink the elixir and gain the strength and powers of their enemies. Just one drop is enough to make the pulse quicken and when the soup is eaten the person eating it is tasting fear, a powerful emotion.”

https://www.cbs.com/shows/criminal_minds/episodes/25348/
An episode called “To Hell” includes a torturing sadist who extracts a fluid from the back of the neck of his victims for ambiguous medical purposes. Episode title similar to famous Dear Boss letter sign-off, From Hell.
http://criminalminds.wikia.com/wiki/Lucas_Turner
“He would then extract viable material from the bodies with a syringe, which he would use (along with medical equipment he stole on the same days as when he abducted some of his victims) in Mason’s experiments.”
This medical angle is an addition with no basis in the case being used, I checked.

https://www.imdb.com/title/tt3232530/
“Buchan explains that the killers are cannibals, eating their victims to assume their power and goodness.
Odd it was cancelled directly after this plot. There was a cannibal cult but the details were murky.

I wonder if it relates to religious “spiritual ties” or “ties that bind”, you could think of it as drinking a young, pure or good person’s good karma to absorb it.

Could karma be chemical in part? We know good lifestyle choices do boost physical health, including abstention (as in celibacy and fasting).

http://forever.wikia.com/wiki/Fountain_of_Youth
Brain protein shakes and a shady company spokesman who seems kinda like Thiel. Company name Aterna similar to Ambrosia.
https://www.imdb.com/title/tt3776150/trivia
“ask the suspect if the Ribowsky method was used when removing the pituitary gland
“The medical advisor on the show is Shiya Ribowsky.”
So the science of the pituitary was generally right.
They were stolen while ‘fresh’ by an EMT in the plot, odd detail to include.

Found these while looking for this
https://futurism.com/fountain-youth-effect-young-blood-old-mice/
https://futurism.com/first-results-of-a-clinical-trial-to-cure-aging-using-young-blood-just-came-in/
“The idea of injecting plasma to combat the effects of aging comes from a 19th-century concept that’s now referred to as parabiosis. In its earliest iteration, the skin of old and young mice was stitched together to allow blood to circulate freely between the two animals.”
What they don’t say: it killed the young mouse.

“Between the study results and the fact that caregivers might be predisposed to observe improvements where there are none, it’s being argued that the study is far from conclusive.”
They still say it’s a positive finding.
“Alkahest, the technology company that bankrolled the study, finds the results encouraging. Further trials are set to be carried out to determine whether or not the treatment is at all viable.”
You’ve done that already, answer was no.
“Another study will take this a step further and only use the part of blood plasma that contains growth factors, which has proven to be more effective in animal testing.”
Vague ‘growth factors’ – it wasn’t tested in 1914, was it?

https://www.newscientist.com/article/2152064-first-results-from-young-blood-alzheimers-trial-are-criticised//

It has nothing to do with that condition, that’s the sell.

http://www.nature.com/nm/journal/v20/n6/full/nm.3569.html
Entirely from aged mice’s perspective. It isn’t medically safe to study only one party of two but then again, young donors might sue for health damage and years off their lifespan.

Meanwhile
http://www.cell.com/cell-reports/fulltext/S2211-1247(18)30156-6
“Mimicking an aged condition in young adults by abrogating Tet2 expression within the hippocampal neurogenic niche, or adult neural stem cells, decreased neurogenesis and impaired learning and memory. In a heterochronic parabiosis rejuvenation model, hippocampal Tet2 expression was restored.”
So they looked at young examples, switched off an expression and turned it back on again? That isn’t science.

“We next asked whether mimicking an age-related decline in Tet2 within the young adult hippocampus would impair neurogenesis. We first abrogated Tet2 expression in the young adult hippocampus utilizing an in vivo viral-mediated RNAi approach (Figure 2A). Young adult animals were stereotaxically injected with high-titer lentivirus (LV) encoding Tet2 or scramble control small hairpin RNA (shRNA) sequences into the DG of contralateral hippocampi, and Tet2 abrogation was confirmed in vivo”
So they can damage your brain by injection, nice to know.

I feel like the only one who reads this stuff.

TLDR: Don’t trust headlines.

https://sciencebasedmedicine.org/parabiosis-the-next-snakeoil/
“The huckster cycle is beginning again with a treatment called parabiosis. Actually, it is a treatment based on parabiosis, but is not parabiosis itself. The term refers to experiments that were first conducted in 1864 by Physiologist Paul Bert. He cut the skin of two mice, then sewed them together. When they healed together their blood vessels combined, enough so that they essentially shared their circulatory systems.”
In short: the studies they’re doing aren’t true parabiosis, they’re intended to lube us up ethically for some Human Centipede bullshit.

“In the 1950s researchers connected old mice to young mice to determine its effects. They found that the old mice experienced numerous rejuvenating effects. Many biomarkers of youth returned, and the mice lived longer.”

The only side they report in recent studies. The sales side.

The younger mice connected to older mice also had shorter lifespans.”
This is established finding, what happens when you steal finite blood compounds.
The source runs low. It’s elementary mathematics.

The younger mice connected to older mice also had shorter lifespans

“shorter lifespans”

from swapping blood, that’s all, how harmless, right?

Why aren’t the young donors also studied?

That’s why.

If they won’t study half the participants, it’s illegal.

They won’t gather or publish evidence only if it can be used to sue them.

“The mouse experiments convincingly show a benefit from parabiosis for older mice. One question is, does this benefit come from specific factors in the blood or from the fact that they are sharing their entire circulatory system?”

Both, the younger’s body helps the aged purify their own aged blood. They’re ‘borrowing’ heart, liver, kidneys etc. It’s kinda like organ rape.
Nobody asks what happens to the young donor after? Narrative.

“In other words, are the younger mouse’s kidneys, livers, and lungs just supporting the older mouse’s organs by doing the heavy lifting of cleaning and oxygenating the blood? This is probably a factor, but the other option is that there are proteins in the young mouse blood that exist in smaller amounts in the older blood.”
“The latter seems to be true also. Researchers have found that higher levels of oxytocin in young blood, for example, stimulate muscle growth. Factors in the blood also seem to stimulate stem cells in many organs to start dividing again. This may be the main rejuvenating effect, bringing stem cells throughout the body back to life, helping to heal damage, replace cells, and increase organ function”

Then why not an artificial one? Why not make a supplement? Logically, Vitamin C does that!

They haven’t explained why a human sacrifice, partial or complete parabiosis, is needed?

It doesn’t seem to be needed for what they claim.

“Open questions include whether one time transfusions of plasma from young donors (<30) will have any enduring benefit on older recipients.”
Well hang on, first harm none!
If the coffin-dodgers only gain an extra ten years their hippie lifestyles didn’t deserve but the donor loses ten of their life, what then?

“It seems from mouse studies that blood cells are not necessary, just the plasma, which contains all the proteins and hormones that are likely having any effect.”
Thiel doesn’t want the plasma. It’s quite clear that’s a show. Plasma carries other compounds. You can buy plasma from any lab, it cannot just be plasma to justify the financial cost.

I swear if I got a dollar every time I stated the obvious, I’d be richer than Thiel.

This is not brain surgery, it’s a matter of business capital. What can he offer nobody else can?

Critically – are there any risks or side effects? The mouse research revealed what was called parabiosis disease. In an experiment with 69 mouse pairs, 11 of them died quickly. It is believed this was from some incompatibility, a form of rejection.”

Nope, but I’m keeping mum about what it was.

“This has been reduced in later experiments by using genetically matched inbred mouse strains. So – how carefully matched do the plasma donors have to be to the recipients?”
If the donor is a fetus or stolen placenta with pluripotent cells, that wouldn’t be an issue.

“Some researchers object to the notion that young plasma transfusions should be considered “rejuvenation.” No cells are being rejuvenated, they are just being stimulated into working harder. This may provide a temporary benefit, but is unlikely to significantly affect aging.”
If anything, since cell division is finite, they’ll feel better but die sooner.
Wouldn’t that be awful?

Newborn Human Baby Blood Shown to Reverse Age Related Diseases.
A recent scientific study published in the scientific Journal Nature has born out the possibility that components of the blood of newborn human babies could actually reverse many of the problems associated with cognitive and other impairments due to aging.”

Problem? How are the wages of sin the problem of the rest of us?

You didn’t want the Government interfering in your body, did you?
Now you can’t ask it to interfere with others’ bodies on your behalf.

“While this may strike many as a horrific topic with it’s possible implications. Be aware this research is all linked to the scientific journals. A topic not for the faint of heart.”

titled “Human Umbilical Cord Plasma Proteins Revitalize Hippocampal Function in Aged Mice”

http://www.nature.com/articles/nature22067.epdf

…So does tea in humans.

Asking this important question. What is the age of the blood needed for the maximum effects? Citing the scientific literature from the Journal Nature. Any of the recent articles on the Parabiosis and the elite’s fascination with it all reference the same report in the journal Nature. Missing the most telling part of the report entitled Ageing research: Blood to blood.

This was only a couple paragraphs down from the material covered in the mainstream pieces. Mainstream media outlets must have lost interest after only a couple paragraphs.

Clive McCay, a biochemist and gerontologist at Cornell University in Ithaca, New York, was the first to apply parabiosis to the study of ageing. In 1956, his team joined 69 pairs of rats, almost all of differing ages3. They linked rats included a 1.5-month-old paired with a 16-month-old — the equivalent of pairing a 5-year-old human with a 47-year-old. It was not a pretty experiment. Journal Nature Ageing research: Blood to blood.

“Pairing the equivalent of an 18-year-old with a 47-year-old produced only negligible results. ”

What they’re waiting to tell you, boiling the frog.

“Whereas pairing that same 47-year-old with a 5-year-old produced much better results.”

New form of pedophilia? What would that be? Pedophagy?

“Mining the components of the young blood to enhance the function of an older host. All of this is certainly not good for the young donor being sucked dry of its vitality.”

Putting it lightly. It’s basically the machine in Princess Bride taking years of your life away.

Wait, literally. That’s literally it. 

I guess it’s like socialism, they coerce you into agreement by promising you can benefit later too. Only the idiots wouldn’t realize this would only even them out (taken one, given one) much like other Ponzi e.g. pensions, where the money given later is inflated to worthlessness. What are you gonna do, sue the long-dead people? You trusted an illegal IOU (slavery) from people already screwing you? “Don’t trust anyone over 30”.

OT I wonder if this woman was harvesting from her African slaves.
https://en.wikipedia.org/wiki/Delphine_LaLaurie

Back to the paper.

http://www.nature.com/articles/nature22067.epdf

Regarding this experiment it was not injecting young mouse blood into older mice. Injections of actual newborn human blood plasma from donated umbilical cords were given to older mice.”

I dispute “donated”, there is pressure involved in harvesting. Talk about objectification, right? Harvesting female body parts.
Mothers aren’t told their babies need that umbilical blood for brain function and to delay cord cutting as long as possible. Don’t cut until it stops pumping (into the baby’s body).

“The experiment was related to aging research and not Alzheimer’s disease as is often quoted in mainstream articles when broaching the need for such macabre experiments.”

I hate people who skim headlines and act like they read the paper for this reason. It takes two minutes to read the abstract.

https://www.sciencemag.org/news/2016/08/young-blood-antiaging-trial-raises-questions

“Before the infusions and 1 month after, their blood will be tested for more than 100 biomarkers that may vary with age, from hemoglobin level to inflammation markers.”
Let’s see the list.

“Karmazin was also intrigued by the story of a Russian physician named Alexander Bogdanov, who in the 1920s gave himself infusions of young human blood that he claimed boosted his energy level and bestowed a more youthful appearance. There are “overwhelming data” suggesting that young plasma will be beneficial to people, Karmazin says.”
Plasma doesn’t make you look younger.

I haven’t seen any of that data either.

This is reverse Robin Hood medical abuse.

The participants won’t necessarily be elderly, making it hard to see any effects, and there are no well-accepted biomarkers of aging in blood, he says.”
Try adrenochrome?

translation: we have no good findings and don’t expect replicable answers, this is science! we wear lab coats and everything! still give us money!

http://www.naturalnewsblogs.com/parabiosis-elite-transfusing-blood-young-original-research-funded-rockefeller-foundation/
Rockefeller research, as capped.

Almost done, paper vomit and the best connection left last.

Parabiosis paper:

https://www.physiology.org/doi/abs/10.1152/physrev.1952.32.3.277?journalCode=physrev
By far the most numerous investigations ….involving pituitary-gonad interrelations.”

https://www.researchgate.net/publication/260094325_A_revival_of_parabiosis_in_biomedical_research

https://www.fightaging.org/archives/2017/11/a-review-of-the-recent-history-of-parabiosis-research/
“contradictory research results to date” – last year end

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938334/
Parabiosis in mice, in detail

Parabiosis doesn’t help skin
https://www.ncbi.nlm.nih.gov/pubmed/17579342

Parabiosis and stem cells
https://www.ncbi.nlm.nih.gov/pubmed/23489470

Doesn’t really work
https://www.ncbi.nlm.nih.gov/pubmed/26540176
suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies. Many highlighted recent reports on systemic tissue rejuvenation combine parabiosis with a “silver bullet” putatively responsible for the positive effects.”

translation We need real metrics and results. Look busy!

“Attempts to unify these papers reflect the excitement about this experimental approach and add value in reproducing previous work. At the same time, defined molecular approaches, which are “beyond parabiosis” for the rejuvenation of multiple old organs represent progress toward attenuating or even reversing human tissue aging.”

trans. We need to move on from it before investors figure this out.

https://www.ncbi.nlm.nih.gov/pubmed/23470554
“therefore, factors that are rapidly cleared from the circulation do not reach equilibrium across the parabiotic union whereas those with a long half-life achieve a uniform concentration and bioactivity in both members of a pair.”
“the obese mouse lacked a circulating signal that regulated energy balance, whereas the diabetic mouse appeared insensitive to such a signal”

As you can guess, this is why they don’t want other adults, capable of informed consent.

They need something fresh and pure.

Original document
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266980/
“Adrenaline and adrenochrome by David Ezra Green and Derek Richter”
April 1937
Same:
http://www.biochemj.org/content/31/4/596

Where’s the science, they ask?
https://www.sciencedirect.com/science/article/pii/0003986151902858
“The adrenochrome redox system”

A 1999 paper I can see some interest in, insufficient to connect.
https://rd.springer.com/article/10.1007%2FBF03033271

https://www.sciencedirect.com/science/article/pii/S0306987703003190
Schizophrenia and cancer: the adrenochrome balanced morphism 2004

“There is experimental evidence that appears to support this possibility. Matrix Pharmaceuticals Inc. has received a US patent covering the composition of IntraDose Injectable Gel. This gel contains cisplatin and epinephrine (adrenaline) and is designed to be injected directly into tumour masses. Cisplatin is a very powerful oxidant which will almost certainly rapidly convert the adrenaline to adrenochrome. While the manufacturers of IntraDose consider cisplatin to be the active cytotoxic agent in IntraDose, it seems more likely that adrenochrome and its derivatives may, in fact, be more effective.”

Like they DON’T KNOW.

Puh-LEASE.

“IntraDose gel has undergone or is undergoing a series of Phase III open-label clinical studies, being injected into patients’ tumours that have been identified as the most troublesome by their physicians. The results have been impressive for breast cancer, malignant melanoma, esophageal cancer and cancer of the head, neck and liver.”

If they’re profiteering off this too, that sounds like Big Pharma.

If you’re wondering why so many celebrities would take such a thing.

The most interesting lead today.

A Victorian Marxist
https://en.wikipedia.org/wiki/Alexander_Bogdanov
with a psychopath stare.

Contemporary of Crowley.

Such a Marxist, in fact:

http://www.marxists.org/archive/bogdanov/index.htm

“He maintained that the party could only work through illegal organizations”

they call him “ultra-left” and he was kicked out.

Marxists.org call him Ultra Left.

That’s enough for one day.

“China’s gonna rule the world!”

This is a long race.

http://nationalinterest.org/blog/the-buzz/scary-statistic-chinas-debt-gdp-ratio-reached-257-percent-22824

Scary Statistic: China’s Debt to GDP Ratio Reached 257 Percent in 2017

O.K. Chiaboo.

https://chinapower.csis.org/aging-problem/

“China’s population is growing old at a faster rate than almost all other countries….”

http://www.pewglobal.org/2014/01/30/chapter-2-aging-in-the-u-s-and-other-countries-2010-to-2050/

B-b-b-but America’s population is aging!

Read the chart and tell me which continent is fucked.

http://www.socialmatter.net/2017/05/19/myth-20th-century-episode-19-malthus-discontents-population-policy/

“In particular, the U.S. population is projected to grow faster and age slower than the populations of its major economic partners in Europe and Asia. “

Now, who has the least young people? Read the chart.

Now read this one.

“Countries in Asia and the Middle East are also turning gray rapidly. The median age should increase by 16 years in South Korea, from 38 in 2010 to 53 in 2050.24 Double-digit increases are also expected in India, China, Indonesia, Pakistan, Iran, Egypt and Turkey. The median age in China, Iran and Turkey is younger than the U.S. at the moment but should become older by 2050.”

“Japan currently has the oldest population in the world, and the median age there is projected to increase from 45 in 2010 to 53 in 2050. South Korea is expected to catch up to Japan by 2050 as its median age also increases to 53 by mid-century. By then, the median age in Germany (51), Italy (50) and Spain (50) will not be far behind. China’s population, with a median age of 46 in 2050, is expected to be older than those in Russia, France and Britain by that date.”

Consider these percentages in light of total population (millions or billions).

It isn’t a question of IF the Chinese start eating each other (again), but when.

Double dependency in two generations.

Which continent, total populations considered, is the most fucked?

Oh but it might peak by 2070?

https://www.sciencedaily.com/releases/2017/06/170621145126.htm

I don’t think they can wait that long. They aren’t sustainable now.

What does Bloomberg know?

https://www.bloomberg.com/news/articles/2018-02-05/china-s-next-debt-bomb-is-an-aging-population

http://www.scmp.com/news/china/economy/article/2132236/chinas-ageing-population-creating-new-debt-crisis-beijing-pension

Cannibals

https://www.rfa.org/english/news/china/cannibalism-11222013104349.html

 [Then premier] Liu Shaoqi is reported to have said this to [then supreme leader] Mao Zedong: “When people start eating each other, it’ll be my name and yours that are written down.” We don’t know what discussion this referred to, nor what came after this remark…. At the time, I thought to myself at the time: “Cannibalism. Well that’s huge. And it has even come to the knowledge of Mao Zedong.” But I still had no basis [to believe it was true]. The [ruling Chinese] Communist Party is a very secretive organization.

But the head of the Anhui police department … wrote a report [during the 2000s] in which he said that [there had been] 1,289 cases of cannibalism reported in the province in 1960. That’s 1,289 cases. These were considered “special cases.” That’s the name they gave to cases of cannibalism.

Recently, I have received another article. It’s an official document that was sent for forwarding to an office in Gansu province. It’s a report written by an investigative team that was sent to the province…. It documents nearly 50 cases. Here it shows you the time, and the rural work unit the people belonged to, and the names of those involved, and who it was that they ate, and how they ate them.

Here’s one: “Ma Waiyou, of Maiji commune, Xinmin village. Status: common peasant. He ate Chen Zaxi. Relationship: spouse. He ate his own wife. He dug up her body and cooked it.”

A cruel race.

Here’s another: “Yang Wenyi and Yuan Shuying of Houxiyan village together with … eight people in total, dug up the body of a child, cooked and ate it.”

Here’s another, at the Xihe commune. A person called Liu Chuan. “They killed him and ate him….”

This is a secret report carried out by the Chinese Communist Party itself…. Mao Zedong knew about this…. Many more reports will come out like this, when those files are finally opened. This was an era of cannibalism.

Q: So there are official accounts?

A: There’s one … about a labor camp in Gansu … where there were more than 3,000 “rightists.” Now some prisoners in labor camp get special privileges. They might get extra grain, or they might be allowed visits from their relatives, things like that. This is in return for special jobs they do. There are three people here, named. Wei Changhai. Rightist. His job? To sell dead bodies.

When I was in labor camp, there was a guy like that. He drove the truck out every day to sell dead bodies. Sometimes I went with him. They all had enough grain to eat, those guys. He looked pretty healthy…. They were so strong, not like us who looked like we might keel over any minute. We asked our brigade leader why this was, and he said, “I’ll show you something.” He took us to the graveyard, which was a huge area of wasteland where they would dig pits, throw in the bodies, and then cover them up again.

It was a ghastly chaos. One would have an arm broken, another a leg missing, one would be naked. He dug one up and said “Look!” The body’s clothing was ripped open and their chest had been cut open too. There was no flesh on the body’s bones. It was skin on a frame of bone. You couldn’t eat the flesh on those bodies because there was nothing on them. But when we looked inside, we saw that the heart, liver, and lungs were gone.

Communism. Greed is a deadly sin.

Caloric restriction and famine deadly for men, but not women

Women have more genetic material to cushion the blow, otherwise we wouldn’t be capable of producing both sexes.

Men certainly have the weaker hand at a raw level.

You could see civilization as a way to protect men who’d otherwise be booted out the tribe at the first sign of competition or war or would otherwise die early from fighting in a natural environment. There’ll always be an evolutionary need for women, and society ensures men live much longer than they previously did, by decades. The men who would’ve killed them keep them on as labour with the promise of a mate who would’ve otherwise rejected them, lacking the ability to dominate the local arena.

https://www.aftau.org/weblog-medicine–health?=&storyid4704=2308&ncs4704=3#GeneticMemoryofStarvationMayCurtailLifespanofMen

The researchers arrived at three major discoveries: (1) There were shorter leukocyte telomeres in men born after 1923 after the mass famine ended than in men born before 1922; (2) there was a stable inheritance of shorter telomeres by men born in ensuing generations; and (3) there was an absence of any correlation between shorter telomeres and women born before or after the event.

I guess you could be cruel and say those men are the children of failure r-types who couldn’t hunt or grow enough food (eating the seed crop, high time pref) and this is natural selection weeding them out of the gene pool.

“This study, while demonstrating that starvation has the potential to shorten telomere length, raises several questions,” said Prof. Kobyliansky. “Does starvation exert a stronger effect on telomere length in the reproductive cells of adults than in the leukocytes of children? Is starvation-induced telomere shortening a sex-dependent phenomenon? And would fasting regimens exerting beneficial effects be accompanied by telomere shortening in descendants?”

yes obviously duh, less pluripotency, filing this under epigenetics because it involves the germline
yes look at the findings there is clear effect on one side and FA on the other
depends, like anything dietary

The face-slappingly obvious Darwinian explanation is that women need to be biologically hardier since, with our numbers dropping, the species risks extinction. sperm is cheap, eggs are expensive again

Famine may be an epigenetic punishment for poor foraging behaviours, that acts like a genetic disease without being strictly genetic in origin.