Men lose Y-chromosome with age

https://www.sciencedaily.com/releases/2016/05/160523212527.htm
That’s why they die earlier.

Really.
Stop blaming women and ‘sexism’, we aren’t omnipotent gene meddlers.
Also, genetic proof of a male wall. LOL. An explanation to why so many middle-aged men suddenly look like lesbians.

[coughs in Bruce Jenner]

And there’s no way to reverse it, before the snake oil salesmen jump up with a solution that, if it worked, would make them a billionaire.

Nobel winner.

World famous.

Popping pills to get out of laziness is what lefties do.

Bold for the lazy.

Using new tools to analyze genetic variations that accumulate with age, we can help explain how sporadic diseases like cancer or Alzheimer’s manifest,” says first author Jan Dumanski.

One such postzygotic mutation found in the cells of biological males is the loss of the Y chromosome in a degree of blood cells. Loss of Y occurs in up to 17 percent of men and is more likely to be found in older men and men who smoke. This study expands on the idea that loss of Y, already a known risk factor for cancer (10.1038/ng.2966), could be a predictive biomarker for a wider range of poor health outcomes, specifically Alzheimer’s. Why loss of Y can be linked to an increased risk for disease remains unclear, but the authors speculate it has to do with reduced immune system performance.

They should look at age groups of men.

And diet.

IMHO.

The researchers looked at over 3,000 men to ascertain whether there was any predictive association between loss of Y in blood cells and Alzheimer’s disease. The participants came from three long-term studies that could provide regular blood samples: the European Alzheimer’s Disease Initiative, the Uppsala Longitudinal Study of Adult Men, and the Prospective Investigation of the Vasculature in Uppsala Seniors. Across the datasets, those with the highest fraction of blood cells without a Y chromosome were consistently more likely to be diagnosed with Alzheimer’s.

….Really more of an outcome of poor genetic health….

Did you test for aluminium?

Attempt chelation therapy?

Yeah, fuck the easy solution, blame the Y chromosome.

Like women don’t get it.

“Having loss of Y is not 100 percent predictive that you will have either cancer or Alzheimer’s,” Forsberg says, adding that there were men in the study who had the mutation and lived with no symptoms well into their 90s.

Were their fathers older or younger?

If paternal age is a factor in ANYTHING, it’s a risk factor for this.

Male chromosome plus mutation. Come on.

Men think they can fool women but white hairs on a ballsack don’t lie.

“But in the future, loss of Y in blood cells can become a new biomarker for disease risk and perhaps evaluation can make a difference in detecting and treating problems early.”

No shit.

Forsberg, Dumanski, and colleagues will next investigate the effect of loss of Y in larger cohorts and explore in greater detail how it confers risk for specific types of cancers and disease. They also plan to look at the cellular changes caused by loss of Y and how it affects different types of blood cells.The researchers looked at over 3,000 men to ascertain whether there was any predictive association between loss of Y in blood cells and Alzheimer’s disease. The participants came from three long-term studies that could provide regular blood samples: the European Alzheimer’s Disease Initiative, the Uppsala Longitudinal Study of Adult Men, and the Prospective Investigation of the Vasculature in Uppsala Seniors. Across the datasets, those with the highest fraction of blood cells without a Y chromosome were consistently more likely to be diagnosed with Alzheimer’s.”

Should look at heart disease, primary killer of American males.

But that’s none of my business.

If men aged well, they wouldn’t need to be on supplements.
Young men on supplements is just sad, like young women getting plastic surgery.
There’s no room to move. If you can’t be all that young, what are they going to do?
Our society treats aging like cancer, it’s ridiculous Boomer youth cult propaganda to sell them supplements like detox tea and testosterone ball rub. You can’t fool mother nature.

When they actually hit middle-age, they won’t be able to keep up with that crap anyway.
Imagine most of your shallow friends disappearing because you dropped the massive timesink of gym addiction.
The Ken Doll homoerotic gym attention bros look sad after about 40.

Plus bodybuilder types know there are two types of muscle: appearance and strength.
Guess which one they all go for?

The one that instantly converts to stubborn fat if they so much as look at a complex carbohydrate past 30.

The Johnny Bravo look is actually, industry secret, physically weak.

In a fight, any martial artist will tell you the bulk limits their range of motion like a fatty anyway.

All men need is a healthy range of light muscle, which women prefer but don’t require any supplement sales.
Light muscle also provides cognitive benefits with no musculoskeletal downsides, including sag and joint pain.
Bruce Lee could take a Henry Cavill any day of the week.

With the T&A they have a woman’s hourglass in profile, they gay.

At least, appealing to that market…..

Death is genetic

Especially in the selfish, so the self-destructiveness of liberals (drugs, homosexuality, abortion, STDs) really is a feature, not a bug.

We already know sexual selection is genetic (r/K, HBD inheritance) so obviously natural is too.

https://motherboard.vice.com/en_us/article/we-are-programmed-to-die-early-and-thats-a-good-thing

If death is gene-mediated, then who is programmed to live longer, r-types or Ks?

“Bar-Yam and his colleagues are arguing that natural selection actually favors traits that self-limit consumption and reproduction, not selfish maximalism, including lifespan limiting mortality. In other words, organisms may be able to have longer lifespans than they presently do, but natural selection has actually favored individuals that clock themselves out early.”

Unclear. Probably K but the variables are iffy.

They’re partially basing off the false idea that more reproduction is always good/favoured by evolution when actually it was responding to the selection pressure of high mortality. Now mortality is low, they should include quality, the alpha genes for the race between the sexes.
Fitness is not N children, that only applies when there is competition from r-types.

Sexual competition.

In a vacuum, K is superior for a society.

Empires rise with K, die with r.
https://disenchantedscholar.wordpress.com/2017/05/29/rk-is-timeless/

“Aside from August Weismann—who in 1882 did actually argue that death was programmed—it’s because when they considered the effect of evolutionary selection, they were taking averages across organisms and their environments instead of considering each individual organism in its local context. By removing the individual from its particular place or location within a given population, this average ignores the complex relationship between that individual and its environment.”

READ DARWIN.

“By looking at how an individual’s local context affects their fitness, Bar-Yam and his colleagues were able to show that traits which may be an advantage in the short-term (such as an individual’s longevity or ‘selfish’ resource consumption) can actually be a significant disadvantage in the long term, and vice versa.”

Implying it’s bad for the nation, the wider genetic kin group or thede.

Nature is nationalist.

“While this may work out well for the most selfish individuals in the short term, if Bar-Yam and his colleagues are correct it could be cataclysmic for our species in the long run.
“What people do affects their environment and that affects their ability to survive,” said Bar-Yam. “This is something we’re all well aware of today. If you overexploit your resources, you’re going to be in trouble.”‘

MALTHUS, she said, screaming into the void.

“As Bar-Yam points out, if death is genetically programmed, that also means it can probably be hacked.”

The problem with the autistic, they assume they know better than nature. They don’t even know what all these genes do in all conditions and they want to go chopping them out with CRISPR. You know why CF spread? It protects you from TB.

For those who know jack-shit about evolution: the vast majority of mutations are bad, not just bad but fatal (anti-fitness, dysgenic) and that’s why it’s good when nature throws away the genetic equivalent of a shitty doodle on scrunched-up paper. That’s why humans evolved to die quickly, to spread up the overall rate of mutation as a species but also to conserve gains quickly too with shorter generational duration (more breeding in same time).

How many people deserve to live that long? Will it include youth or the shit years, extended for centuries? Who wants to slave away for centuries, cos they can’t financially retire? Biohacking is fraught with technical issues.

People age at variable speeds (biological age)

http://www.pnas.org/content/early/2015/07/01/1506264112

Antiaging interventions are needed to reduce the burden of disease and protect population productivity.

Translation: they want to work you like a dog until you die.

Young people are the most attractive targets for therapies to extend healthspan

How is that NOT eugenics? You can bet it would be enforced.
Covered here: http://www.bbc.co.uk/news/health-33409604

…The analysis showed that at the age of 38, the people’s biological ages ranged from the late-20s to those who were nearly 60.

Pretty huge variance.

“They look rough, they look lacking in vitality,” said Prof Terrie Moffitt from Duke University in the US.

The study said some people had almost stopped ageing during the period of the study, while others were gaining nearly three years of biological age for every twelve months that passed….

Wouldn’t it make more empirical sense to study the verifiable Dorian Grays of the group?
Could this be genetic load?
Epigenetics with environment?

Taken with other studies, such as caloric restriction, might the body have an optimum stressor rate, beyond which it begins to break down? What could affect this? Processed food, particulate matter (air pollution), toxins processed or physical exertions?

“Any area of life where we currently use chronological age is faulty, if we knew more about biological age we could be more fair and egalitarian.”

I don’t see how. Unless you shoot people for being too young.

She argued the retirement age may be unfair for those “working at their peak” who then had to retire.

Oh, the government wants another excuse not to pay your pension. Fantastic.
It’s also ironic I was writing today about how men have a Wall too. Deny this. We’ve all seen people from school who were late bloomers, as well as people who peaked at age 15.