Ancient European DNA

Once more, I implore and painstakingly EXPLAIN, IF they can breed, they are, by DEFINITION, the SAME species.

http://www.cell.com/current-biology/fulltext/S0960-9822(21)00592-3

Different race? Maybe. Same species? Definitely.

Peştera Muierii woman is related to Europeans, but she is not a direct ancestor

Doesn’t have to be, a lot of bloodlines died.

Reduced diversity in Europe caused by Last Glaciation, not out-of-Africa bottleneck

Natural selection kills diversity. We know this.

Genetic load appears indifferent across 40,000 years of European history.

Postmodern habits like drugs, drinking, bad diet, sleeping around, can screw up your epigenetics over a few generations. We absorb viruses into our genome. Outbreeding depression does it in one. You can, in fact, fuck up tens of thousands of years of effort on part of your ancestors. If only we had a commandment about this.

Pet theory: planes are evil. Sink the boats.

Few complete human genomes from the European Early Upper Palaeolithic (EUP) have been sequenced. Using novel sampling and DNA extraction approaches, we sequenced the genome of a woman from “Peştera Muierii,” Romania who lived ∼34,000 years ago to 13.5× coverage. The genome shows similarities to modern-day Europeans, but she is not a direct ancestor. Although her cranium exhibits both modern human and Neanderthal features, the genome shows similar levels of Neanderthal admixture (∼3.1%) to most EUP humans but only half compared to the ∼40,000-year-old Peştera Oase 1. All EUP European hunter-gatherers display high genetic diversity, demonstrating that the severe loss of diversity occurred during and after the Last Glacial Maximum (LGM) rather than just during the out-of-Africa migration. The prevalence of genetic diseases is expected to increase with low diversity; however, pathogenic variant load was relatively constant from EUP to modern times, despite post-LGM hunter-gatherers having the lowest diversity ever observed among Europeans.

The Neanderthals were human. They were, at most, a race. Basic classification 101. It’s politically incorrect to admit this.

Welcome Global Cooling, it kills off redundant diversity. The people still living are the winners.

OOA is laughable at this point. Multi-Regional is correct. They don’t have to keep tweaking it to fit the data, replete with Black Swans that shouldn’t be there.

Assumption is incorrect, diseases become more serious, the higher the diversity. It’s akin to mixing random chemicals in a beaker. You’re more likely to blow your arm off, the more different the ingredients or elements. Well, mutations work the same way and most are disadvantageous i.e. they lower Darwinian fitness. A novel combination is dangerous. Inbreeding depression takes centuries in a super-restricted, incestuous environment; meanwhile, outbreeding depression occurs in one generation between any two genomes of sufficient distance. Odds are, if a kid has some super-rare obscure disease, barely recorded, they’re mixed race. The more mixed, the more health problems, including mental health. Taboos are based on health outcomes. They demonstrate low fitness for any one environment and ‘fail to thrive’ in either parental environment as a result. It dooms them to never belong and fit in, a core human need as a social species. Every group has a runt to its litter, but that shouldn’t be encouraged as the norm, it’s cruel. Happily, this means such mutants and feeble specimens were almost unheard of throughout our history, so we have nothing to feel guilty about. It’s literally the parent’s fault they made an experimental kid. Nobody forced you to play God.

This is why Africans in Africa are healthier than the mongrels in America. It isn’t just diet. Also why full-blooded Africans generally hate them. They are equally disgusted by the degeneration as any other race, it’s human aversion to disease.

Similarly, White Americans have extremely high white DNA but also suffer poorer health compared to their homelands. Why? Admixture of subrace. The same applies to a lesser-degree within a race, of sufficient genetic distance. It’s unlikely to be fatal, but breeding with a person with high mutations (r-type) will ruin the bloodline of the person whose is low. It’s only fine if they’re both low, which is unlikely when so distant in ancestry as to cross countries (and emigration is r-select). Consider the children of supermodels. Regression to the mean, except mutations only build. So you get a bland, dull looking child, nothing special. Breeding two racehorses is fine, breeding it with a donkey makes a mule, however good the racehorse genes of one parent. That’s the evil of genetic regression. Beware it. A racehorse with a regular horse may be fine but is likely to be uninspiring by the racing parental standard. This also applies to plants and flowers. Excess distance causes fertility dysfunction and is collectively called the process of speciation. Enough of the odd couples die off genetically while others, more natural, succeed and replace them using natural selection (by omission) to win zero sum. It works on a mathematical level. It’s basic game theory. Live or die.

EVOLUTION HAS NO CONTINUOUS SPEED. IT IS AN ONGOING PROCESS AND OPERATES FASTER SOME TIMES THAN OTHERS. I repeat, evolution is non-uniform as a biological driving force to live. I’ve never seen a shred of proof for it being the same everywhere, at all times and in all peoples. That smacks of absurd equalism and doesn’t account for the violence of history, both natural disasters and wars. There is much to the contrary, like this. Bloodlines die out, in part, all the damn time. All the bloody time! Yet certain people who claim to be high IQ like to pretend it has a constant speed like ‘c’, it is a positive claim and I’d like evidence. It doesn’t have to make sense to you, to be demonstrably true.

How many of Edison’s many children survived? Surprisingly few. That’s in a century. Writ large, same pattern. The birth rate doesn’t matter, longevity of genes does. Do not conflate them. Dilution is also a partial death. It’s like genetic atrophy. When children disappoint their parents, whose fault is that?

I find it funny supposed Christians mock evolution, only to insist on muh birth rates. If you believe in Revelations, it won’t matter, because winning is Darwinian. It isn’t about cross-comparisons to other groups, more r-select (read: arrogant while times are good) and their over-populating to over-consume and eventual, frequent famine (hello China), but quality within. Genetics are moreso about what you DON’T have than what you do. i.e. You can’t steal IQ, China, keep funding genetic engineering though. You tried. R-types can only run an ‘Empire’ of inferior quality by oppressing their own kind and even then, it fractures and implodes due to their sadism (low group loyalty > no in-group empathy). They are collectivists who hate freedoms and rights. Introduce more k-select competition and they’re easily brought to heel, like the French. Beaten (and saved) by a nation of shop-keepers. There’s a difference between conspicuous consumption and responsible innovation. R-types can’t tell until it’s all failing and none of their people running the machines (high corruption, nepotism) were smart enough to invent them (low child investment), so cannot fix it. Corrupt societies deserve to suffer and die. Evolution is social as much as genetic. = epigenome

TLDR: With debt bubbles as with population bubbles. It’s the same bubble. Malthus wins.

While K-types look foolish during good times, they lose the least (high child investment pays off) when times get tough and due to high group loyalty, fare better against challenges by more r-groups. Ks have the steadier gene = winning. You don’t buy a Ferrari on credit to compete with your neighbour, you wait for his to get repossessed.

See: Skyscraper Index. Recently: Asian.

This low load of mutations and high fertility into the modern era, suggests Neanderthals were the same race, and they’re trying to report the finding without admitting this. Curse the editors.

nb I wonder whether the RNA trial mutants will be having fertility problems with their own, or only with the rest of us. Speciation is epigenetic.

RNA can be written into DNA

Imagine my shock.

Pause. Wait. Imagine it.

Imagine my shock.

“This work opens the door to many other studies that will help us understand the significance of having a mechanism for converting RNA messages into DNA in our own cells,” says Richard Pomerantz, PhD, associate professor of biochemistry and molecular biology at Thomas Jefferson University. “The reality that a human polymerase can do this with high efficiency, raises many questions.” For example, this finding suggests that RNA messages can be used as templates for repairing or re-writing genomic DNA.

The work was published June 11th, 2021, in the journal Science Advances.

Except we knew this for ages and I’d posted about it before, this just proves it further.

Well duh, messengers don’t just go ONE way?

It’s all part of your epigenome, I explained this before.

Together with first author Gurushankar Chandramouly and other collaborators, Dr. Pomerantz’s team started by investigating one very unusual polymerase, called polymerase theta. Of the 14 DNA polymerases in mammalian cells, only three do the bulk of the work of duplicating the entire genome to prepare for cell division. The remaining 11 are mostly involved in detecting and making repairs when there’s a break or error in the DNA strands. Polymerase theta repairs DNA, but is very error-prone and makes many errors or mutations. The researchers therefore noticed that some of polymerase theta’s “bad” qualities were ones it shared with another cellular machine, albeit one more common in viruses — the reverse transcriptase. Like Pol theta, HIV reverse transcriptase acts as a DNA polymerase, but can also bind RNA and read RNA back into a DNA strand.

DNA polymerase, there’s a term to tuck in your belt.

“Our research suggests that polymerase theta’s main function is to act as a reverse transcriptase,” says Dr. Pomerantz. “In healthy cells, the purpose of this molecule may be toward RNA-mediated DNA repair. In unhealthy cells, such as cancer cells, polymerase theta is highly expressed and promotes cancer cell growth and drug resistance. It will be exciting to further understand how polymerase theta’s activity on RNA contributes to DNA repair and cancer-cell proliferation.”

RNA-mediated DNA repair. Quite an arse covering.

If it can repair, it can damage.

When highly expressed, the process promotes cancer growth? Really? Fascinating. I’ll await the RNA trial results from the control group of organic humans with interest. Extreme interest.

The drug resistance is interesting, that wouldn’t include anti-virals, would it?
To people with tainted RNA, would transcriptase be a kill shot?

Here’s hoping my idiotic relatives don’t shed on me into mutantdom. If they do, I’ll tell you.

The races (sub-species) are biologically distinct and a study on ancient Africans

The races (sub-species) are biologically distinct, QED:
https://genomebiology.biomedcentral.com/articles/10.1186/gb-2002-3-7-comment2007

A debate has arisen regarding the validity of racial/ethnic categories for biomedical and genetic research. Some claim ‘no biological basis for race’ while others advocate a ‘race-neutral’ approach, using genetic clustering rather than self-identified ethnicity for human genetic categorization. We provide an epidemiologic perspective on the issue of human categorization in biomedical and genetic research that strongly supports the continued use of self-identified race and ethnicity.

Parroting a comment I made to Vox for SEO.

And just like white people have other ‘species’ DNA (Neanderthal), so too do Africans (non-Neanderthal).
https://phys.org/news/2011-09-modern-humans-interbred-archaic-hominin.html
I too, fucking love science.

“Instead, we looked at DNA from modern humans belonging to African populations and searched for unusual regions in the genome.”
And they were older than modern. Imagine my shock.
“What we do know is that the sequences of those forms, even the Neanderthals, are not that different from modern humans,” he said.
-BECAUSE THEY THE SAME SPECIES. Sorry, broke into spontaneous ebonics because of the topic.
“They have certain characteristics that make them different from modern DNA.”
No shit?

Could be better or worse depending on the variant. They refuse to clone Neanderthals because no company could own them (human rights are based on demonstration of human IQ) and they’d be the smartest human on the planet. It would show us all up. I want it to happen. Neanderthals were more civilized than us, we learnt funerary rites from them. Please clone the African ancestors too, see what happens.

“Then we asked ourselves what does the general pattern of variation look like in the DNA that we sequenced in those African populations, and we started to look at regions that looked unusual,” Hammer said. “We discovered three different genetic regions fit the criteria for being archaic DNA still present in the genomes of subSaharan Africans. Interestingly, this signature was strongest in populations from central Africa.”
I’ll fly high on this one and say no comment.

“We are talking about something that happened between 20,000 and 60,000 years ago – not that long ago in the scheme of things,” Hammer said. “If interbreeding occurs, it’s going to bring in a whole chromosome, and over time, recombination events will chop the chromosome down to smaller pieces. And those pieces will now be found as short, unusual fragments. By looking at how long they are we can get an estimate of how far back the interbreeding event happened.”
Outbreeding depression…. it isn’t inter-breeding, it’s out-breeding….
“We think there were probably thousands of interbreeding events,” Hammer said. “It happened relatively extensively and regularly.”

He can’t be saying, they were literally fucking monkeys? No. …No? No.
Are they technically humans they were screwing or not? At best, they mixed races. At worst, bestiality. I read a conspiracy that human anatomy is so weird because we’re the result of primates mating with hogs. That’s why pig hearts and such work on us. It was surprisingly detailed and I couldn’t think of anything to counter it.* I am also scared now.

I’m making the odd low/no effort post when I can be asked.

*Also explains the Biblical prohibition on pork.

DNA database collection

Oh, it’s real.

https://www.legislation.gov.uk/uksi/2020/973/made?view=plain

 The condition is that the fingerprints or DNA profiles are retained in accordance with a national security determination that will (ignoring the effect of these Regulations) cease to have effect on a date during the period that starts with 1st October 2020 and ends with 24th March 2021.

(3) The retention of the fingerprints or DNA profiles under the national security determination may continue for a further period of six months starting with the date on which the national security determination would otherwise have ceased to have effect.

Tell me again how Boris is based.

CALLED IT
https://disenchantedscholar.wordpress.com/2018/01/15/why-would-you-hand-over-your-dna/

It’s a database grab, the genetic database’s purpose is to engineer themselves (like the white HIV resistant gene) into superhumans, possibly plant at crime scenes (if you become a problem) and/or re-write history by messing with labels of the ‘ethnic’ groups….

You’ve paid to be a lab rat, you’ve handed them research materials.
This is the most important data you’ll ever have.
They can produce sperm from DNA now.”

2 and a half years ago. I try to warn you all.

But the dudebros don’t listen because cooties ewww.

Inbreeding without depression

https://countryofnowhere.wordpress.com/2016/05/11/inbreeding-in-the-uk/

As in, normal group preference, genophilia. No mutations.

Reminds me of the study that found distant cousins most fecund.

Britons are still living in the same ‘tribes’ that they did in the 7th Century, Oxford University has found after an astonishing study into our genetic make-up. Archaeologists and geneticists were amazed to find that genetically similar individuals inhabit the same areas they did following the Anglo-Saxon invasion, following the fall of the Roman Empire.

In fact, a map showing tribes of Britain in 600AD is almost identical to a new chart showing genetic variability throughout the UK, suggesting that local communities have stayed put for the past 1415 years.

Geneticist Professor Sir Walter Bodmer of Oxford University said: “What it shows is the extraordinary stability of the British population. Britain hasn’t changed much since 600AD.

“When we plotted the genetics on a map we got this fantastic parallel between areas and genetic similarity.

….

The findings also showed that there is not a single ‘Celtic’ genetic group. In fact the Celtic parts of the UK (Scotland, Northern Ireland, Wales and Cornwall) are among the most different from each other genetically.

And the research has finally answered the question of whether the Romans, Vikings and Anglo-Saxons interbred with the Brits or wiped out communities.

The team found that people in central and southern England have a significant DNA contribution from the Anglo-Saxons showing that the invaders intermarried with, rather than replaced, the existing population.

By choice or rape?

But there is no genetic signature from the Danish Vikings even though they controlled large parts of England – The Danelaw – from the 9th century, suggesting they conquered, kept largely to themselves, and then left. Only Orkney residents were found to have Viking DNA.

“We found that 25 per cent of the DNA of someone living in Orkney is from Norse ancestry which suggests that when the Vikings arrived they intermingled with the local population rather than wiping them out,” added Prof Peter Donnelly.

“Similarly the Saxons in Germany have contributed DNA to some of the English groups but not to some of the others. We can see not only the differences in the UK but the reasons for those differences in terms of population movements.”

http://www.ox.ac.uk/news/2015-03-19-who-do-you-think-you-really-are-genetic-map-british-isles#

https://countryofnowhere.wordpress.com/2016/05/20/simple-uk-genetic-maps/

Inbreeding is great if you have low genetic load in the participants, it preserves the health, looks and intellect of the bloodline. The breeding of good breeding was this deliberate sexual selection for fitness. It’s only a problem when you introduce mutations. They compound.

Outbreeding is far more likely to produce diseased or infertile offspring, much like a liger or a mongrel, the depression of mutations in genetic load can occur in a single generation.

Scanning for survivors

https://archive.md/f0O9R

They want to know who to keep alive during the depopulation efforts.

Admitting fitness (g is Darwinian fitness) involves admitting low fitness including the most dysgenic ranges of human specimens ever to exist. We live in an era where multiple generations of imbeciles were allowed to breed and succeed. It corrupts the rest, one rotten apple spoils the barrel. It’s a unique time in history.

The rich outgroup that echoes will steal genius genes from the docile public.

And then there’s no need to keep those aged workers or useless eaters alive, is there?

In an editorial about the genetics of race published in the New York Times on March 23, Harvard University biologist David Reich cited the new genetic IQ predictors and cautioned that “all traits influenced by genetics are expected to differ across populations.”

trans. we know race is real stop blaming us

they also have to admit that “low IQ” is sub-human (an excuse for aggressive sexual deviance found in intellectually disabled populations) or even non-human in the case of basic chromosomal print errors – this is again Darwin 101 and the reason your “pro-science” schools won’t permit his work

“We are in a situation when you mention you work in intelligence, people say, “Oh, you can’t measure that.’

Testing for idiots is rather simple.

Forging transcripts to justify special treatments would also occur.

Equal treatment in education was noble. Slow kids would get extra help, the mass in the middle would get along as quickly as possible to get out and work and the smart ones given extra work when they finished early.

It was a way of boosting every child to their max potential – but you can’t magic potential out of thin air.

Darwin predicted genes and this stuff over a century ago, it isn’t deep.

There are already pressures and stereotypes and biases impairing kid performance, teachers don’t care! They support mixed sex schools that drag down female performance, they support busing in black kids to white schools while claiming the white kids are toxic – same white kids gradeboosting the black kids but dragging their own down. Mixing religions also drags down performance on tests. Employers can’t use IQ tests even when it’s life/death.

Of course environment matters. Have the longest gazelle legs, if the other guy has an AK47 to trap you it won’t matter. The State itself is an IQ shredder.

End pathological altruism of lying to idiots, making them think it’s their fault or someone else that they fail when it’s just fact, like a shortarse trying to jump high, fails.

Stop infantilising bad kids and giving them “support” for being hostile little bullies to the others while your geniuses/tall poppies languish and wither and die, your futures with it.

Otherwise GDP won’t just STAGNATE it’ll COMBUST.

Ancestry tests are impossible

And this, from an Out of Africa theorist.

https://www.garvan.org.au/news-events/news/personal-dna-tests-in-the-spotlight

Especially more than a thousand years ago, come on. What percentage of your DNA is theirs?

One generation ago is 50%….

It should be illegal under privacy laws. You have no right to sell (and sell you do) your relative’s DNA to a company.

Professor Hayes, an expert in ancient ancestry, human origins in Africa and the impact of ancient DNA variation on modern human disease, shared her perspectives on the limitations of different types of testing and the contribution of genetic research to the accuracy of ancestry tests.

Professor Hayes says, “The clear value of these online tests is that they are creating public awareness and debate into the use of genomics as we enter an era of precision medicine, where one’s individual DNA profile will be used to inform one’s medical care.

None of those words are good.

However, the information learned from these tests is only as accurate or informative as the data available.”

learned by?

translation: They aren’t accurate.

Insurance companies want them.

So do biotech. They’re allowed to patent nature (reverse this).

This is the genetic gold rush.

There’s gold in them thar veins!

You’re all Henrietta Lacks.

https://www.smithsonianmag.com/science-nature/henrietta-lacks-immortal-cells-6421299/

So they can come up with a drug worth billions from your DNA and you paid them to do it.

While selling out your relatives for a bullshit questionnaire “result” page that might as well have come from Buzzfeed.

The police can access their database to place you at a crime scene (or plant your DNA at one) and juries are dumb enough to think being somewhere, alive, is the mark of a criminal. (CSI effect)

[only in rape cases, so few rapists nowadays deny any sexual acts took place, as they used to)

You’re only as smart as your dumbest, vainest relation.

They couldn’t get you to sign up to clinical trials willing, plus all the ones applying your code to would add up, so they tricked you into paying them to use you like a guinea pig.

“The majority of these tests to date interrogate no more than 0.02% of our DNA code, which includes over 6 billion ‘letters’. While this is certainly sufficient to determine direct family relatedness,

Who is your daddy?

making further assumptions on complex ancestral structure and more importantly complex diseases, raises serious concerns.”

She adds, “In a research setting our studies require a lengthy process of ethics approval, participant consent, individual de-identification, freedom for study withdraw and highest level of data security, for the very reasons and concerns raised by participants during the SBS insight DNA Surprises.”

Trends in genome scans and sources of error

Cropped link – https://doi.org/10.1111/mec.13339
I’ll be honest, I’m linking this for a stupid reason.
Links to – https://onlinelibrary.wiley.com/doi/abs/10.1111/mec.13339
One author is called Payseur.

Things that make nerds go Ooh.

But yeah, there are tons of methodological issues with DNA tests, exhibit A.

From issue entitled: “Detecting Selection in Natural Populations: Making Sense of Genome Scans and Towards Alternative Solutions”

They’re studying ongoing human evolution, people. They’re biologists.

It isn’t like every mutation-prone cell in the world decided to play nice and stop while they play catch up.

Don’t give away something so valuable the police can’t steal it to a shady faceless corporation with ties to Israel and Google. Mmkay?

Medical ethics quiz round, rhetorical Q:

Is it really a murder if they clone your DNA?

Biologically, no.

Pathogenic cancer DNA change proven

https://www.sciencedaily.com/releases/2018/06/180627160355.htm
Study STDs. Dare ya.

“The research, published in the journal eLife, shows that the human leukemia virus (HTLV-1) acts at a large number of sites across the human genome, disrupting the regulation of tens of thousands of genes.”

One virus.

One strain, of one virus.

“HTLV-1 is thought to infect more than 10 million people around the world. The virus can be transmitted through unprotected sex, blood transfusions, and from mother to baby via breast milk.”
Harmless fun. Fuck a Thai girl, kill your baby. Who are you to judge? They aren’t hurting anyone. What the wife doesn’t know, won’t hurt her. – Satan

“They add that the findings provide new insight into how viruses like HTLV-1 can alter the structure of the human genome, which can result in diseases such as cancer.”

The wages of sin.

When will it be taught in Sex Ed?

Never ever ever ever.