Alcohol, DNA mutation and evolution

https://www.cancer.gov/about-cancer/causes-prevention/risk/alcohol/alcohol-fact-sheet

Michael Douglas’ cancer was probably caused by alcohol.

All alcohol causes permanent DNA mutation. Over time it builds up.

Researchers have identified multiple ways that alcohol may increase the risk of cancer, including:

Alcoholic beverages may also contain a variety of carcinogenic contaminants that are introduced during fermentation and production, such as nitrosaminesasbestos fibers, phenols, and hydrocarbons.

Is there a racial difference?

You bet.

Can a person’s genes affect their risk of alcohol-related cancers?

A person’s risk of alcohol-related cancers is influenced by their genes, specifically the genes that encode enzymes involved in metabolizing (breaking down) alcohol (13).

For example, one way the body metabolizes alcohol is through the activity of an enzyme called alcohol dehydrogenase, or ADH. Many individuals of Chinese, Korean, and especially Japanese descent carry a version of the gene for ADH that codes for a “superactive” form of the enzyme. This superactive ADH enzyme speeds the conversion of alcohol (ethanol) to toxic acetaldehyde. As a result, when people who have the superactive enzyme drink alcohol, acetaldehyde builds up. Among people of Japanese descent, those who have this superactive ADH have a higher risk of pancreatic cancer than those with the more common form of ADH (14).

Another enzyme, called aldehyde dehydrogenase 2 (ALDH2), metabolizes toxic acetaldehyde to non-toxic substances. Some people, particularly those of East Asian descent, carry a variant of the gene for ALDH2 that codes for a defective form of the enzyme. In people who have the defective enzyme, acetaldehyde builds up when they drink alcohol. The accumulation of acetaldehyde has such unpleasant effects (including facial flushing and heart palpitations) that most people who have inherited the ALDH2 variant are unable to consume large amounts of alcohol. Therefore, most people with the defective form of ALDH2 have a low risk of developing alcohol-related cancers.

However, some individuals with the defective form of ALDH2 can become tolerant to the unpleasant effects of acetaldehyde and consume large amounts of alcohol. Epidemiologic studies have shown that such individuals have a higher risk of alcohol-related esophageal cancer, as well as of head and neck cancers, than individuals with the fully active enzyme who drink comparable amounts of alcohol (15). These increased risks are seen only among people who carry the ALDH2 variant and drink alcohol—they are not observed in people who carry the variant but do not drink alcohol.

Few epidemiologic studies have looked specifically at the association between red wine consumption and cancer risk in humans.

Video: Who owns your body? [DNA]

I’m not saying where you should look.

I’m not saying where you should pause this video to read carefully.

I’m not saying you shouldn’t become a guinea pig to any test, just know what the test really is about.
Taking whatever is unique about you, and buying it.

Plus, the other thing.

https://www.geneticsandsociety.org/article/dna-evidence-can-be-fabricated-scientists-showhttps://www.forensicmag.com/news/2015/02/dna-evidence-can-be-faked

“DNA is only as good as the records you keep.”

Experts asked What causes intelligence?

http://journal.frontiersin.org/article/10.3389/fpsyg.2016.00399/full

Gee, I wonder…

Education was rated by N = 71 experts as the most important cause of international ability differences. Genes were rated as the second most relevant factor but also had the highest variability in ratings. Culture, health, wealth, modernization, and politics were the next most important factors, whereas other factors such as geography, climate, test bias, and sampling error were less important. The paper concludes with a discussion of limitations of the survey (e.g., response rates and validity of expert opinions).

You can’t educate a dunce into a genius.

Note that the countries with the best of many of those factors? Have the highest IQs too. Almost like IQ is causing some of them….

Nature: Old fathers, sick babies

The people pushing a “Father at Any Age, Just Find a Young Woman” model are just as evil as the female counterparts. You can’t trick nature. Who would deliberately stall and put their descendants in such an injured, sickly position? Monsters. ‘Have It All’ is impossible. Family or party, pick ONE.

http://www.nature.com/news/fathers-bequeath-more-mutations-as-they-age-1.11247

Fathers passed on nearly four times as many new mutations as mothers: on average, 55 versus 14.

The father’s age also accounted for nearly all of the variation in the number of new mutations in a child’s genome,

with the number of new mutations being passed on rising exponentially with paternal age.

A 36-year-old will pass on twice as many mutations to his child as a man of 20, and a 70-year-old eight times as many, Stefánsson’s team estimates.

Go ahead, deny the damage of mutation load, I dare you. Let’s see if you’re redpill and accept the genetic data or a narcissist just like the ‘career women’ coldly leaving it as late as possible.

Nature is very clear that, given the option, youthful parents (18-25) are the better parents (genetically) in both sexes.  How could any sane person, educated in genetics, see it any other way?

By starting families in their thirties, forties and beyond,

The manosphere is doomed to comparative genetic inferiority.

men could be increasing the chances that their children will develop autism, schizophrenia and other diseases often linked to new mutations.

The super-classy myth of blaming older (supposedly feminist?) mothers for child autism is also wrong, if you look up the data, which points to a paternal and grand-paternal age link. Nor does it make basic logical sense that a Male Brained neurological problem would be passed on from anyone other than the father (that Y chromosome?). As more data is taken, this connection will only get stronger, so a word to the unwise: quit putting it off, idiots.

Naturally, the other options are genetic suicide (probably a good idea for this selfish type, imagine what awful parents they’d be) and/or mudsharking/outbreeding, since they can’t get a higher status (usually) white woman, which also, as covered in the mixed post, causes psychiatric issues. Those two races did not co-evolve, the material conflict fundamentally, it’s like mixing oil and water. Especially half Asian/half Europeans, like …Elliot Rodger.

wow omg omfg how can you be so dumb really stupid fyi

Yeah, that’s an angle I never covered. 100% true.

inb4 an embittered shriveled egg joke, that will not be a problem
http://news.nationalgeographic.com/news/2012/02/120229-women-health-ovaries-eggs-reproduction-science/

Link: Google want to steal your genome

OOOOO-OF COURSE THEY DO.

http://www.bloomberg.com/news/articles/2015-10-20/-your-genome-isn-t-really-secret-says-google-ventures-s-bill-maris

hahaha fuck you

This ‘data’ could be used to, among other things, clone you, kill you, all your descendants and relatives and/or be used against you (you know this would be admissible in court, right?) What about My Body, My Choice? The original property right is one’s body. Body is made of DNA. Ergo, Property = DNA. Nobody else owns it. That’s slavery.

Meanwhile, they’re dancing around the means this is possible, HBD, like a Maypole.

The one piece of data that makes you unique. Your ultimate property. Why do they want it, if not to use it or sell it? It isn’t theirs. They have no authority we don’t give them, and they’re playing God. Sue them, America. Sue them into oblivion if they try to pull this.

Link: The decline and Neanderthal DNA

http://vault-co.blogspot.com.au/2010/11/anyone-who-appears-to-be-able-to-reason.html

Thus far, the genetic studies have vindicated this position, to my knowledge.

http://www.livescience.com/7153-scientist-humans-strange-neanderthals-normal.html
There are a race of human: http://www.livescience.com/1122-neanderthal-99-5-percent-human.html

But excavations and anatomical studies have shown Neanderthals used tools, wore jewelery, buried their dead, cared for their sick, and possibly sang or even spoke in much the same way that we do. Even more humbling, perhaps, their brains were slightly larger than ours.

The results from the new studies confirm the Neanderthal’s humanity, and show that their genomes and ours are more than 99.5 percent identical, differing by only about 3 million bases.

Telegony proof racks up

You heard it here first: https://disenchantedscholar.wordpress.com/?s=telegony

This is a good breakdown of the evidence, remember Roosh studied biology, he isn’t pulling this out of his ass.

http://www.returnofkings.com/70425/research-suggests-that-a-womans-body-incorporates-dna-from-the-semen-of-her-casual-sex-partners

….Telegony is an idea first proposed by Aristotle that claims offspring can inherit genes from the mother’s previous sexual partners. This idea was not scientifically supported until evidence piled up of microchimerism, the phenomenon of foreign DNA becoming incorporated into the genome of an individual. This was first noted to happenin the case of blood transfusions. If you have received blood while in a state of trauma, your donor’s DNA can become incorporated into your genome. Surprisingly little research has been done on microchimerism since then, but all signs point to this being a widespread and common genetic phenomenon throughout the animal kingdom.

A groundbreaking study on flies last year showed the process of females incorporating DNA from previous male partners and then exhibiting that male DNA into future spawn they had with completely different males…..

The problem with men would be STDs, since they usually pass them on. Neither sex gets a free pass, since STDs can cause miscarriage or birth defects (the original reason for warnings).

I’ve always thought of the uterus as a fertile field, the old seeds are still there, somewhere. They can’t exactly go anywhere.

Interesting headline: http://www.telegraph.co.uk/news/science/science-news/11133203/Could-previous-lovers-influence-appearance-of-future-children.html

There is a side of this which dissuades promiscuity in men too. Every slut you’ve ever slept with (without a condom) could claim a section of Child Support, because some of your DNA is present.

Not to mention this exchange would equally apply to men too. Both sexes have mucous membranes. French kissing and sublingual absorption of DNA? Saliva and other female bodily fluids?

Fair airing of rebuttal;

http://scienceblogs.com/pharyngula/2015/09/09/mra-science-madness/

Most of the guy’s arguments are “We don’t have the data to say that.”

Which is fair. It was speculation from limited studies.

And inaccurate.

What is truthful is to say “We don’t have the data yet and let’s test it!”

But he doesn’t want to test it.

How scientific.

Study: Jew genes found (Jewish racial profile)

http://www.einstein.yu.edu/news/releases/509/study-finds-genetic-links-among-jewish-people/

The title is crass but there’s no other way to put it.

Using sophisticated genetic analysis, scientists at Albert Einstein College of Medicine of Yeshiva University and New York University School of Medicine have published a study indicating that Jews are a widely dispersed people with a common ancestry. Jews from different regions of the world were found to share many genetic traits that are distinct from other groups and that date back to ancient times.

The study also provides the first detailed genetic maps of the major Jewish subpopulations, a resource that can be used to study the genetic origins of disease. The findings appear in the June 3 online issue of the American Journal of Human Genetics. …

http://www.cell.com/AJHG/abstract/S0002-9297(10)00246-6

Free PDF here: http://www.cell.com/ajhg/pdf/S0002-9297(10)00246-6.pdf

Abstract

For more than a century, Jews and non-Jews alike have tried to define the relatedness of contemporary Jewish people. Previous genetic studies of blood group and serum markers suggested that Jewish groups had Middle Eastern origin with greater genetic similarity between paired Jewish populations. However, these and successor studies of monoallelic Y chromosomal and mitochondrial geneticmarkers did not resolve the issues of within and between-group Jewish genetic identity. Here, genome-wide analysis of seven Jewish groups (Iranian, Iraqi, Syrian, Italian, Turkish, Greek, and Ashkenazi) and comparison with non-Jewish groups demonstrated distinctive Jewish population clusters, each with shared Middle Eastern ancestry, proximity to contemporary Middle Eastern populations, and variable degrees of European and North African admixture. Two major groups were identified by principal component, phylogenetic, and identity by descent (IBD) analysis: Middle Eastern Jews and European/Syrian Jews.

The IBD segment sharing and the proximity of European Jews to each other and to southern European populations suggested similar origins for European Jewry and refuted large-scale genetic contributions of Central and Eastern European and Slavic populations to the formation of Ashkenazi Jewry. Rapid decay of IBD in Ashkenazi Jewish genomes was consistent with a severe bottleneck followed by large expansion, such as occurred with the so-called demographic miracle of population expansion from 50,000 people at the beginning of the 15th century to 5,000,000 people at the beginning of the 19th century. Thus, this study demonstrates that European/Syrian and Middle Eastern Jews represent a series of geographical isolates or clusters woven together by shared IBD genetic threads.