Estrogen and lifelong brain health, testosterone fraud

https://www.ncbi.nlm.nih.gov/pubmed/26109339

Estrogen facilitates higher cognitive functions by exerting effects on brain regions such as the prefrontal cortex and hippocampus. Estrogen induces spinogenesis and synaptogenesis in these two brain regions and also initiates a complex set of signal transduction pathways via estrogen receptors (ERs). Along with the classical genomic effects mediated by activation of ER α and ER β, there are membrane-bound ER α, ER β, and G protein-coupled estrogen receptor 1 (GPER1) that can mediate rapid nongenomic effects. All key ERs present throughout the body are also present in synapses of the hippocampus and prefrontal cortex. This review summarizes estrogen actions in the brain from the standpoint of their effects on synapse structure and function, noting also the synergistic role of progesterone. We first begin with a review of ER subtypes in the brain and how their abundance and distributions are altered with aging and estrogen loss (e.g., ovariectomy or menopause) in the rodent, monkey, and human brain. As there is much evidence that estrogen loss induced by menopause can exacerbate the effects of aging on cognitive functions, we then review the clinical trials of hormone replacement therapies and their effectiveness on cognitive symptoms experienced by women. Finally, we summarize studies carried out in nonhuman primate models of age- and menopause-related cognitive decline that are highly relevant for developing effective interventions for menopausal women. Together, we highlight a new understanding of how estrogen affects higher cognitive functions and synaptic health that go well beyond its effects on reproduction.

Men dosing testosterone are called meatheads for a reason, they would logically throw off their other hormones and functionally retard themselves. Because this ONE time, you can trust the pill people. No IQ studies in testosterone supplementing men, I guess there’s a good reason. They just forgot?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330791/

The results are, unfortunately, controversial and puzzling. Dosing, timing, even the application route seem to considerably affect the outcomes. 

You’re not trying to rig it at all, huh?

Reduction to dihydrotestosterone by 5-alpha reductase increases the androgen activity; conversion to estradiol by aromatase converts the androgen to estrogen activity.

Holy shit.

That’s hilarious.

Recently, the non-genomic effects of testosterone on behavior bypassing the nuclear receptors have attracted the interest of researchers. This review tries to summarize the current understanding of the complexity of the effects of testosterone on brain with special focus on their role in the known sex differences.

Not known.

a very important study in rhesus monkeys showed that pharmacological castration reduced and testosterone supplementation normalized anxiety levels (Suarez-Jimenez et al., ).

on the other hand, in both men and women, testosterone supplementation leads to improvement of depressive symptoms (Pope et al., ; Miller et al., ). However, not all interventional studies confirmed the anti-depressant effect of testosterone. At least in one published randomized controlled trial, the effects of testosterone were comparable to placebo effects (Seidman et al., ). Similarly, not all observational studies show a consistent picture. At least in one small study, depressive women had higher testosterone (Weber et al., ).

Another experiment on intact rats revealed that the effect of testosterone on depression is dose-dependent (Buddenberg et al., ).

Over the counter won’t work.

During the productive ages and even in early adulthood, men generally outperform women in spatial abilities (Linn and Petersen, )

Even for a few years you’re in college? Is that it?

Spatial thing is probably due to error, thus would be discounted under a valid method.

Error rate as well as the reaction time negatively correlated with testosterone (Hooven et al., ).

In another study, actual testosterone was not associated with spatial abilities, but prenatal testosterone correlated positively with spatial abilities in women (Kempel et al., ).

Congratulations, you’re on the female level. Apply your non-toxic internet cream.

In line with these findings is the lack of an association between actual salivary testosterone levels and mental rotation in men and women (Puts et al., ).

Actual science, no replication issue.

However, in a large observational study analyzing spatial abilities in adult men from various age categories, low testosterone was associated with better spatial visualization (Yonker et al., ).

Actual science, no replication issue.

Plus multiple ages in ADULT men, important.

Good work.

In a very interesting study, it was found that in men, the pubertal concentrations of testosterone are negatively associated with mental rotation in the adulthood (Vuoksimaa et al., ). In the same paper, the comparison of twins is reported. The twin with higher testosterone scored worse in the mental rotation tests. The results are contradictory, but may depend on the test used for the assessment of spatial abilities.

Counting fluke correct answers and not errors to force a finding is scientism. Bad method.

When virtual Morris water maze was used, a positive correlation between testosterone and spatial navigation was found in women, but not in men (Burkitt et al., ). The size of the corpus callosum seems to add complexity in the relationship between spatial abilities and testosterone (Karadi et al., ). This might be one of the causes for negative findings in studies where some of the determinants are missing (Kubranska et al., ). Another cause is likely the selection of the tested population. In gifted children, a negative correlation between salivary testosterone and spatial abilities was found (Ostatnikova et al., ).

FFS.

Negative findings are real science.

And that’s important.

In Chinese men, the accuracy in mental rotation tests was comparable to Americans, but the reaction times were longer indicating that cultural differences could add to the variability of published results (Yang et al., ).

No they didn’t rush the test out of boredom. Lower error rate, I’d bet.

Last but not least, genetic factors likely modulate the effect of testosterone. We have previously shown that at least in gifted boys, genetic polymorphisms influencing testosterone metabolism affect also its relationship to mental rotation (Celec et al., ). Especially, the CAG short tandem repeat in the exon 1 of the androgen receptor gene seems to be important for the action of testosterone and its metabolites (Nowak et al., ). Despite all complexity, the current picture indicates that the association between testosterone and spatial abilities is curvilinear and sex-dependent.

aka more is NOT better and it’s genetic, morons

In women higher testosterone is associated with better mental rotation, in men lower testosterone is associated with better spatial abilities. This seems to be true both for actual testosterone (Moffat and Hampson, ) and for prenatal testosterone (Grimshaw et al., ). Supplementation of testosterone in older men results in improvement of spatial abilities, but it is accompanied with changes in estradiol metabolism and it is likely that this interferes with modifications of spatial abilities (Janowsky et al., ).

They only studied spatial, not global, I checked.

Even in rats, testosterone administration affects the strategy of the animals in spatial tasks (Spritzer et al., ). However, the interaction between testosterone and mental rotation tests is bidirectional. It has been shown that mental rotation testing affects testosterone, at least in women (Durdiakova et al., ).

Doing smart things causes the brain to…. adapt? Really?

Does our pulse increase when we run? Some Sherlock Holmes do a fucking study.

MRI

Moreover, participants with complete androgen insensitivity syndrome presented with female-like neural activation pattern in the parietal lobe, indicating that gonadal hormone exposure rather than genetic sex itself plays role in brain functions (Van Hemmen et al., ).

Supplementing won’t work, you’re worse than the trannies. They don’t claim brain benefits.

The menstrual cycle and thus the involvement of sex hormones, including testosterone, in spatial abilities was further confirmed by Pletzer et al. In their study, error rates linked with deactivation of inferior parietal lobes and prefrontal lobes were higher during luteal phase for verbal tasks, while in the follicular phase, spatial abilities in females were confirmed (Pletzer et al., ).

One of the major factors that might explain the differences between the results of various studies is the variability of the examined populations. As mentioned above, the cultural differences, sex and age have all been shown to impact the physiological effects of testosterone. 

Duh.

Standardization in this area would surely improve our understanding of the neuroendocrinology of testosterone. More systematic research using the whole spectrum of available tools and looking at the various physiological aspects is needed. However, to be able to publish such research, journals should accept manuscripts based on the design and not on the results. Otherwise, the publication bias that is obvious in the so far published literature will continue to be a big issue. Many researchers in this field complain about negative results that are very difficult to publish in the relevant journals. The number of such unpublished observations and experiments is unknown. But based on our humble experience, the negative results will probably be more common than the published positive ones. And if the contradictory published findings are added, the picture gets even more confusing. Large systematic research projects with more cooperation between the most productive research teams is definitely needed.

You can’t because the low IQ men will complain if you publish negative findings.

e.g.

https://ohsu.pure.elsevier.com/en/publications/testosterone-influences-spatial-cognition-in-older-men-2

Testosterone plays a role in the organization of behavior during development. The authors examined whether testosterone could play a maintenance role in behavior as well. In a double-blind manner, verbal and visual memory, spatial cognition, motor speed, cognitive flexibility, and mood in a group of healthy older men who were supplemented for 3 months with testosterone were assessed. The increase in testosterone levels to 150% of baseline levels resulted in a significant enhancement of spatial cognition, but no change in any other cognitive domain was found.

You’ll be slightly more able to parallel park. Like when you were young.

Louder for the slow:

no change in any other

cognitive domain was found

NO IMPROVEMENT IN MEMORY

NO IMPROVEMENT IN MOTOR SPEED

NO IMPROVEMENT IN COGNITIVE FLEXIBILITY

NO IMPROVEMENT IN MOOD.

Did I stutter?

Testosterone supplementation influenced the endogenous production of estradiol, and estradiol was found to have an inverse relationship to spatial cognitive performance. These results suggest that testosterone supplementation can modify spatial cognition in older men; however, it is likely that this occurs through testosterone’s influence on estrogen.

I’m sure the health effects will be golden.

Aluminium kinetics in the brain

Vaccine Aluminum Travels Into The Brain

Parents can be reassured that the trace quantities of aluminum in vaccines can’t possibly do harm.
-Dr Paul Offit: Vaccine promoter, vaccine patent licensor, and autism pundit, 2015

…the existing evidence on the toxicology and pharmacokinetics of Al adjuvants…altogether strongly implicate these compounds as contributors to the rising prevalence of neurobehavioural disorders in children.
-Dr Chris Shaw, Neuroscientist and aluminum researcher at University of British Columbia, 2013.

But it was assumed that the AANs dissolve rapidly in body fluids, and the resulting Al3+ is eliminated in urine, just like ingested aluminum. However, this simple model is wrong.

assumed by who?

Any asshole can assume, that isn’t science.

Vaccine promoters assume that Al adjuvant is safely eliminated by dissolution and urinary excretion. Thats why vaccine promoters believe only the blood concentration of Al3+ is important. We now know this is wrong. The Al adjuvant dissolves very slowly and so can remain in the body for many months or years. Also, its not just the dissolved Al3+ thats toxic; the Al adjuvant particles are also toxic. 

If you wanted to fuck up little white boys, brain damage is a primary candidate.

Cripple their best resource, right?

The above model is wrong. What actually happens is a type of immune cell called a macrophage (MF) ingests (called “phagocytosis”) the AANs. Eating foreign material is a primary function of MFs. When MFs detect bacteria or debris, the MFs eat it, and destroy it with enzymes.

The problem is that AANs are not digested by the MF enzymes. Consequently, the AANs remain inside the MFs for a long time. The AANs can persist for years. MFs that consume the AANs become highly contaminated with aluminum, and spread the aluminum wherever they go. And they go everywhere in the body.

Sounds like a chemical weapon.

The MFs travel across the blood brain barrier (BBB) when there is inflammation in the brain. The MFs, once loaded with AANs, act like a Trojan Horse and carry the AANs into the brain. This is harmful, because the brain is very sensitive to aluminum.

Below is a diagram illustrating how AANs travel around the body and into the brain.

Shame parents for not injecting the child with poison, because peer pressure to conform is more important than ‘first harm none’.

Herd immunity’s a myth anyway, even 100% coverage (impossible) wouldn’t work. Covered previously.

Soil fertility makes a nation happy

Funny how nature do that.

Antidepressant Microbes In Soil: How Dirt Makes You Happy

“Soil microbes have been found to have similar effects on the brain and are without side effects and chemical dependency potential.”
“Did you know that there’s a natural antidepressant in soil? It’s true. Mycobacterium vaccae is the substance under study and has indeed been found to mirror the effect on neurons that drugs like Prozac provide. The bacterium is found in soil and may stimulate serotonin production, which makes you relaxed and happier. Studies were conducted on cancer patients and they reported a better quality of life and less stress. Lack of serotonin has been linked to depression, anxiety, obsessive compulsive disorder and bipolar problems.

Let kids play in dirt!

(Deport the people who’d attack kids playing outside!)

The bacterium appears to be a natural antidepressant in soil and has no adverse health effects. These antidepressant microbes in soil may be as easy to use as just playing in the dirt. Most avid gardeners will tell you that their landscape is their “happy place” and the actual physical act of gardening is a stress reducer and mood lifter. The fact that there is some science behind it adds additional credibility to these garden addicts’ claims.

They were already credible since all mood is self-reported.

But okay.

The presence of a soil bacteria antidepressant is not a surprise to many of us who have experienced the phenomenon ourselves. Backing it up with science is fascinating, but not shocking, to the happy gardener. Mycobacterium antidepressant microbes in soil are also being investigated for improving cognitive function, Crohn’s disease and even rheumatoid arthritis.”

Why were the WW2 generation and prior so intelligent?

This is why things like scrubbed, sterilised food and the cozy air conditioned gym are so decadent – go outside and dig a fucking trench, you lazy worm.

There’s also a reason all soldiers worth their salt train outside. You’re not just learning the motions and showing off to a bunch of anorexic fags, you learn to move in the elements.

Gyms are for lightweights, the ancients considered them gay brothels but an alarming number of straight men bought the instawhore propaganda that so much homoerotic body obsession is manly and women like it.

Nooooooooooo.

omnia vanitas, I picture above every gym

It’s so anti-traditional, hostile to logic and artificial.

Show me one feminine woman ‘training’ in a gym. Go ahead. Doesn’t happen. Women know better, to be useful when expending our fewer calories. Ideally making money with your labour instead of straight up time wasting on asscheek validation. Very nice, move on with your life. It’s a climate controlled wimpy environment. If a slight breeze or downpour throws you off, you’re basically a child. The bulk fools nobody. The climate also demands a response, keeping all those twitch muscle fibres and instinctive movements attuned to the real world, not snowflake air conditioned HPV bench land. The HPV must be thick in the air in some places, thanks air con!

Meanwhile, nature:

“Antidepressant microbes in soil cause cytokine levels to rise, which results in the production of higher levels of serotonin. The bacterium was tested both by injection and ingestion on rats, and the results were increased cognitive ability, lower stress and better concentration on tasks than a control group.

Some of the most brittle people you’ll ever meet are broflakes who ‘missed’ their baby protein shake, it’s hilarious. Like soyboys and their burnt Starbucks excuse for a ‘coffee’. Why not suck it all from a giant titty cup and stop kidding yourself? Freud would love this. Talk about oral fixation.

Gardeners inhale the bacteria, have topical contact with it and get it into their bloodstreams when there is a cut or other pathway for infection. The natural effects of the soil bacteria antidepressant can be felt for up to 3 weeks if the experiments with rats are any indication. So get out and play in the dirt and improve your mood and your life.”

I’m tired of tolerating excuses from adults to stay indoors like you’re all afraid of nature. But oh yeah, your ‘guns’ are gonna save you in the Apocalypse, alright…

God forbid a plant scratches you though, you take a dive like a French football team and start sobbing manly tears of gym strength.

It’s unnatural to perform naturally outdoor hobbies indoors. Previously, that was confined to hospital gyms for the elderly. It’s a con. Go outside and stop hoovering up SSRIs and talking about gym endorphins. You’re there for the beauty pageant of closeted poofs. Muh gains, brah. Don’t bother growing a single fucking tomato with all those wasted calories. The gym is manual labour you pay to do.

Serotonin soil paper:
http://www.sage.edu/newsevents/news/?story_id=240785

We don’t need Big Pharma, Big Pharma needs us.

Gyms are also huge business for pussies scared of a little rain.

I doubt Podesta’s indoor gardens, with the constantly jamming water systems, are so nourishing from the soil.

Eat your aluminium, thots

That’s right, smear on a lipstick full of shimmery bullshit. Including lead (and wonder why girls are depressed). [Literally eating lead.]

The Victorians ate arsenic but this is worse. Arsenic temporarily improved the complexion.

Using the term ‘mica’ for what’s essentially powdered foil suggests women wouldn’t want it if they knew what it was.

It isn’t like there’s a connection between dissected and tested Alzheimer’s plaques and aluminium deposits, is there?

Why are the Boomers raised on cans of this stuff seeing an explosion in Alzheimer’s rates?

As always, at first, go to the ‘officials’. Find out the Party Line.

https://www.alzheimers.org.uk/about-dementia/risk-factors-and-prevention/metals-and-dementia
Although aluminium has been seen in amyloid plaques”

K.

“there is no solid evidence that aluminium is increased in the brains of people with Alzheimer’s disease.”
Whew, what cognitive dissonance.
It’s literally forming those plaques that ARE the disease but nbd?

Solid evidence – like a solid chemical analysis of solid plaques in the solid brains of solid dead people with Alzheimer’s?

Look at the hustle to move those goalposts.

https://www.sciencedaily.com/releases/2007/08/070813185007.htm
“Because some people with the disease had aluminum deposits in their brains, it was thought that there was a direct connection…”
Well… yeah.
That’s proof.
There’s no negative evidence possible for that to stop being proof.

It’s literally in their brains.

“However, after many years of study, no conclusive evidence links aluminum to neurodegenerative disease”
Bullshit, 2007.

I detest scientism. Look at these papers and tell me what’s ‘conclusive’.

(Apart from donations of mega-corps to Super PACs to prevent this mega-lawsuit).

“A multi-institutional team of researchers has defined for the first time how metal ions bind to amyloid fibrils in the brain in a way that appears toxic to neurons. Amyloid fibrils are linked to the development of neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Creutzfeldt-Jakob. Although metal ions, most notably copper, can bind to amyloid in several specific ways, the researchers found that only one way appears toxic.”

But how, ‘critics’ argue, could this possibly occur? What’s the mechanism? Nobody has proven a mechanism….?

2011:

“Link between Aluminum and the Pathogenesis of Alzheimer’s Disease: The Integration of the Aluminum and Amyloid Cascade Hypotheses”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056430/

“In particular, the link between aluminum and Alzheimer’s disease has been the subject of scientific debate for several decades. However, the complex characteristics of aluminum bioavailability make it difficult to evaluate its toxicity and therefore, the relationship remains to be established.”

Uhuh. Isn’t that your job?

If it’s impossible, why are you getting paid?

“On the contrary, aluminum is a widely recognized neurotoxin that inhibits more than 200 biologically important functions and causes various adverse effects in plants, animals, and humans.”

True.

Mounting evidence has suggested that significance of oligomerization of β-amyloid protein and neurotoxicity in the molecular mechanism of AD pathogenesis. Aluminum may play crucial roles as a cross-linker in β-amyloid oligomerization.

Here, we review the detailed characteristics of aluminum neurotoxicity based on our own studies and the recent literatures. Our aim is to revisit the link between aluminum and AD and to integrate aluminum and amyloid cascade hypotheses in the context of β-amyloid oligomerization and the interactions with other metals.”

But HOW could this POSSIBLY operate? – intellectually dishonest douches.

Note the prestige of journal. International Journal of Alzheimer’s Disease, those hacks.

But on a MOLECULAR level…. – douchecanoes.

https://www.onlinelibrary.wiley.com/doi/10.1002/jms.739
“Quantification of the Aβ peptide in Alzheimer’s plaques by laser dissection microscopy combined with mass spectrometry”

It’s behind a paywall but it’s there. Check the academic pirate bay.

http://orthomolecular.org/library/jom/2000/articles/2000-v15n01-p021.shtml
It’s been known for a while.
2000: “Aluminum has been identified as a neurotoxin for over 100 years.”

So stop using it in food, cosmetics, deodorant, cookware and cans?

Their use actually came in well after it was a known neurotoxin. Because that isn’t dodgy.

Reference for that sentence:

Doelken P:Naunynschmiedeberger. Arch Exp Pathol Pharmakol 40: 58-120 cited by Crapper McLachlan DR., Lukiw WJ, Kruck TPA, Aluminum, altered transcription, and the pathogenesis of Alzheimer’s disease. Environ Geochem Health, 1990; 12(1-2): 103-114.

Link for that: https://link.springer.com/article/10.1007/BF01734059

Opening paragraph.

“The etiology of some, if not all, cases of Alzheimer’s disease is linked to a mutation in the proximal portion of the long arm of chromosome 21∶21q11.2 → 21q22.2. While the functional consequences of the mutation are unknown, we speculate that one consequence of the mutation is loss of the natural barriers and intracellular ligands for aluminum. As a result, aluminum gains access to several brain sites including the nuclear compartment in certain neurons of the central nervous system.”

I know both my shit and my bullshit.

1990. Who owns the aluminium? That’d be a fun tour of genocide.

https://www.onlinelibrary.wiley.com/doi/abs/10.1002/ana.410310310
1992 laser study, note prestige of journal.

What the fuck do they know, right, reddit?

“Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer’s disease: A laser microprobe (LAMMA) study”

“In addition, probe sites directed to neurons identified in snapfrozen cryostat sections from 2 subjects with Alzheimer’s disease revealed similar spectra with prominent aluminum‐related peaks, confirming that our findings are not related to exogenous contamination through fixation, embedding, or other procedures prior to analysis. This study further confirms the association of aluminum and neurofibrillary tangle formation in Alzheimer’s disease.”
1992.

But I guess I’m just scared of non-stick pans, where’s the evidence?

Pig brains revived hours post-mortem

But go ahead, be an organ donor!

https://www.sciencedaily.com/releases/2019/04/190417132805.htm

You won’t feel a thing!

“Circulation and cellular activity were restored in a pig’s brain four hours after its death, a finding that challenges long-held assumptions about the timing and irreversible nature of the cessation of some brain functions after death.”

Long-held?

These are the people you trust to know when you’re actually dead.

They might as well be informed by entrails.

Nerve damage in white males

Coincidental, just don’t look around.

https://www.sciencedirect.com/science/article/abs/pii/S0940299399800724

“The aim of this study was to investigate the effects of squalene on the central and peripheral nervous systems in rat at the ultrastructural level. Squalene was administered at a dose of 20 g/kg body weight, once daily for 4 days, and the animals were sacrificed 7 days and 30 days after the initiation of the experiment. After 7 days a mild swelling of mitochondria and dilation of the Golgi complex cisterns in few neurons in the cerebral cortex and hippocampus were observed. The swelling of astrocytes and their processes was also seen. Some myelin sheaths in the cerebral white matter were disintegrated. In the peripheral nervous system (the sciatic nerve), a damage of the Schwann cells, a destruction of the myelin sheaths, and lipid-like deposits between myelin lamellae causing a secondary compression of axons were present.”

Mercury also destroys myelin sheaths. However, it is eventually cleared from the body by chelating factors in the diet, with the exception of repeat doses e.g. from amalgam.
Why are modern boys slow in school, weirdly dulled and heavy addicts of social media, porn etc.?

Squalene administration caused a stimulation of fibroblast to synthesize collagen and an activation of macrophages in the perineurium.”

The collagen bit makes it fine topically for vain women (including moi).

“After 30 days, the lipid-like material was present in some neurons as well as in the myelin sheaths in the central nervous system. Endothelial cells were hypertrophic and a few demonstrated features of apoptosis.”

I find it odd a famous billionaire magically had a son who “grew out of” autism…

Italians supposedly tested a vaccine in December and found it …didn’t contain a vaccine. At all.
So technically, the things labelled and given as ‘vaccines’ cause issues.

What’s being called vaccinegate is this mystery mix death potion sold and forced on children as “vaccines”.

“Vaccinegate: Initial results on Infanrix Hexa chemical composition”
http://data.over-blog-kiwi.com/1/47/73/60/20190101/ob_d9ff7d_corelva-rapport-composition-vaccin-in.pdf

Almost like genetic targeting, but you’d need enough dumb ones submitting free samples for “research” in the T&Cs to make that a bioweapon.
You’d also need to own the labs and pharmaceutical companies. Do they use squalene?
https://www.cdc.gov/flu/protect/vaccine/adjuvant.htm See end.
Male genes are easier to target than female but the rumour is that the three-part tetanus (no such thing, it’s one-shot) is intended to prevent pregnancy.

In Infanrix Hexa we found
● chemical contamination from the manufacturing process or cross-contamination with other manufacturing lines;
● chemical toxins;
● bacterial peptide toxins;
● insoluble and indigestible macromolecule that reacts to the protein assay, but cannot be recognized by any protein databases.

We have not found:
● Protein antigens of diphtheria toxoids, tetanus, pertussis, hepatitis B, haemophylus influenzae B, Poliomyelitis 1-2-3;
● Formaldehyde and glutaraldehyde, phenoxyethanol, antibiotic residues indicated in the composition;

Autism symptoms is not autism, polio symptoms is not polio.

Note the wording.

https://www.iflscience.com/health-and-medicine/us-outbreak-paralysis-may-have-been-caused-newly-identified-virus/

“May”

I may be George Soros in a wig. Long odds but…. maybe.

Would there happen to be perineurium damage?

https://www.nbcnews.com/health/health-news/cdc-still-stumped-cause-mystery-paralysis-kids-n750276

I fucking bet they are. Bet you squalene antibodies in their bloodstream, easily resolved with another injection for the immune system to attack said antibodies.

They won’t pay out the Social Security bennies.

CDC:

FLUAD is a standard-dose, three-component (trivalent) inactivated flu vaccine, manufactured by Seqirus that contains an adjuvant. FLUAD is designed specifically for people 65 years and older.

Uhuh. Which adjuvant is this?

MF59 is an oil-in-water emulsion of squalene oil. Squalene, a naturally occurring substance found in humans, animals and plants, is highly purified for the vaccine manufacturing process. FLUAD is approved for use among people 65 years and older, who often have a lower protective immune response after flu vaccination compared to younger, healthier people.

I hate being right.

I hate it, I hate it, I hate it.

Feminine brain, youthful brain

https://www.smithsonianmag.com/smart-news/womens-metabolic-brain-age-around-three-years-younger-mens-180971425/

Predictable.

“New research suggests that women’s brains stay energized well into old age, making their brains appear about three years younger than men’s of the same chronological age.”

Given

https://disenchantedscholar.wordpress.com/2015/11/07/estrogen-boosts-brainpower-actually/

Linked in first:

https://www.pnas.org/content/early/2019/01/29/1815917116

Men didn’t evolve to live long, so it isn’t so much remarkable that women live longer with healthier brains but men,  to be competitive with other men in youth and war, age terribly simply because so few would survive there’s no evolutionary pressure.

Some tough choices ahead for the cooties crowd.

Stick to imaginary phantasms of 20th century masculine superiority solely intended to run up credit debt or actually be healthier.

Here comes the academese:

“Researchers remain uncertain why such metabolic differences exist”

EVOLUTION.

“It’s not that women’s brains seem to age slower than men’s,”

Literally is.
Watch the twist.

“Rather, it seems that women’s brains start off at a younger age when they reach adulthood, and they keep that throughout the remainder of their adulthood, basically buying them a few extra years.”

Not how it works. At all.

It’s like saying you start a race at the finish line, words have meanings.

If they’ve reached adulthood, they’ve reached adulthood. You can’t change the meaning to be quantum. Women mature faster (partially from earlier puberty and slower, longer sum development time because of that) and go on to metabolically age better because testosterone is known to burn out the system.

Gradual puberty + lower T = good for long-term brain health.

aka Not women’s fault. Help your fellow men. Maybe that explains why celibates like Tesla (who, let’s face it, probably didn’t masturbate), who kept their T-levels low as a result, lived longer and stayed lucid. Maybe that’s why monks live longer too, staying sharp. Male chastity has observable benefits.

The autobiographies of genius seem to evidence longer average puberty, too. The sensitive kid who’s a later bloomer?

The Victorians called masturbation self-abuse because the compulsion/addiction would tend to be co-morbid with other mental problems, including depression. How many porn addicts are depressed?

And what do they do to self-soothe because (someone) tells them it’s unanimously ‘good for you’?

Even nuns tend to live longer which does point to lower testosterone being a pre-requisite for a long life, neatly explaining why male levels gradually lower. It isn’t like evolution is picking on men. Aggressive animals have shorter lifespans across species. This is the price of being the protector/provider sex.

https://www.healthline.com/health-news/men-too-much-testosterone-linked-to-shorter-lifespan-112213

“Overall, men with circulating testosterone levels between 9.8 to 15.8 nmol/L range tended to live the longest.”

Men are entitled to know what their healthy levels should be, study them!

Men age faster cognitively, he’s like a magician trying to switch your attention onto women when there’s a medical problem with men.
Assuming they want to live long and prosper.

Like, sorry, if that’s a sexist assumption.

“Previous studies have found that aging women often exhibit stronger reasoning, memory and problem-solving skills than males of the same age. But it’s unclear whether this trend is related specifically to metabolism or to a different aspect of brain function.”

Hormonal interaction.

“This might mean women are a little bit more resilient to certain aspects of brain aging in general, but it could also introduce certain vulnerabilities,”

Lying liar. Not even one example? How can you try to spin a youthful brain as a bad thing?

Women aren’t so much MORE resilient (although oestrogen helps) but men are MORE fragile.

HELP THEM.

“Having a younger brain for longer could make the brain more vulnerable to certain things as well.”

Still no mention of men? This isn’t a woman’s issue, there’s nothing new here as stated, women already perform better as a known overall finding*, he totally ignores what men need because it involves admitting they aren’t the best at something….

These arrogant men are sex traitors. Their ego won’t let them admit men need help. So have fun with higher neurodegeneration risk because one guy won’t admit he’s not #1 at everything.

Men are not the control group, it’s the mean between both groups.

Basic category error and erroneous maths.

Hubris is a deadly sin. Treating male ill-health like it’s normal will literally kill men.

OT but relevant:

If we took men as the control, the shorter male lifespan is not only normal but hinted at being desirable, you don’t want to change the norm, with women being unusually longer-lived (greater distance from norm). Actually, the average is between the groups, again. The difference from the norm is smaller, easier to broach and bring those below it up to speed.

*Because unlike IQ studies, they can’t conveniently ‘exclude’ the left-side of the male bell curve to skew their findings dishonestly. This happens after they sample from middle-class academia pupils largely from suburban populations, a huge bias/filter itself.

Sure, throw other men under the bus and blame women for biology. Sexism both ways!

Reminder: