The Aluminium Age and Alzheimer’s

Where’s the science?

https://link.springer.com/chapter/10.1007/0-387-23226-5_11
https://www.sciencedirect.com/science/article/pii/S0162013409001731
https://www.sciencedirect.com/science/article/pii/S1878535215001914

“The results demonstrated that Al(III) induced the transformation of the initial random coil structure to the β-sheet configuration in the Aβ40 peptides. These structural changes facilitated the aggregation of Aβ40.”

Meanwhile, denial train. Choo choo!

https://www.alzheimers.org.uk/about-dementia/risk-factors-and-prevention/metals-and-dementia
“Here’s the evidence behind the presence of metals such as copper, zinc, iron and aluminium.”
The first three are needed by the body and not neurotoxins.
“But the evidence doesn’t yet show whether this relationship actually causes Alzheimer’s disease.”
Have you tried checking?
“It is also unclear whether reducing metals in the brain via drugs or reducing our exposure would have any effect.”
It is unclear whether Caesar was stabbed but there is a lot of blood and all these knives might’ve had some effect.
“These metals are essential to the healthy function of our brain,”
100% LIE.
Aluminium is not necessary for any bodily function.
But it makes food manufacturing dirt cheap!


“The body is able to tolerate these metals in small amounts by clearing through the kidneys. ”

Well, clearly not.

These include aluminium and lead, for example it has been shown that if they are not taken out by the kidneys through organ failure or by exposure to extremely high doses these metals are able to deposit in the brain.
These metals are known to cause negative effects in the brain and have been implicated in several neurological conditions.”
Safe as lead, guys!
And no that’s outdated, the body doesn’t really clear it. See end.
“In 1965, researchers found that rabbits injected with an extremely high dose of aluminium developed toxic tau tangles in their brains. This led to speculation that aluminium from cans, cookware, processed foods and even the water supply could be causing dementia.”
But the can manufacturers were slipped a bribe because they recently had to switch from toxic tin.
That generation’s children now seem to be presenting with unprecedented Alzheimer’s…. coincidence?
“Importantly, these results were only seen with extremely high exposures that far exceed the levels that can enter the body through food or potentially through contact with aluminium cookware.”
That limit does not exist and assumes perfect health – no alcoholism, polluted air, toxic water, stress, chronic diseases.
“As yet no study or group of studies has been able to confirm that aluminium is involved in the development of Alzheimer’s disease.”
Ethics and finding the funding.
Also a half-lie, there are many studies. As you’ll see.
“Aluminium is seen in the normal, healthy brain.”

…..No?

No, it isn’t.
Not ever. Not at all.
It shouldn’t get past the barrier.
Normal for the modern world is not healthy.

Opening line here: “Aluminium is neurotoxic.”
https://www.ncbi.nlm.nih.gov/pubmed/24779346

Back to the liars:

“Although aluminium has been seen in amyloid plaques there is no solid evidence that aluminium is increased in the brains of people with Alzheimer’s disease.”
Yes there was, you’re ignoring it.

They dissected Alzheimer’s patients and found it in there.
Blatant lie.

No convincing relationship between amount of exposure or aluminium in the body and the development of Alzheimer’s disease has been established.”
Wait before it didn’t exist and in the very next sentence, it isn’t convincing?
“Aluminium in food and drink is in a form that is not easily absorbed in to the body. Hence the amount taken up is less than 1% of the amount present in food and drink.”
Bullshit. It’s the most processed form it goes through the whole digestive tract and then into the bloodstream like food nutrients.
Less than 1% – per meal or drink. PER meal or drink.
Comforting?
“Most of the aluminium taken into the body is cleaned out by the kidneys.”
Outdated.
And wouldn’t it be the liver?
“failed to find a convincing causal association between aluminium exposure in humans and Alzheimer’s disease.”
Give us the data instead of finding excuses to hide it.
1991, before the cash cow was in full milking rotation
https://www.researchgate.net/publication/21345082_Aluminium_amyloid_and_Alzheimer’s_disease
“exposure to aluminium has been implicated by epidemiological studies and the finding of aluminium in the cerebral plaques and tangles.”
3 decades later? Still covering it up?
While they blame copper:
https://www.keele.ac.uk/research/researchnews/2012/metalsandtheamyloidcascadehypothesisofalzheimersdisease.php
It’s neuroprotective.
“a high brain tissue ratio of copper to aluminium protects against neurotoxicity associated with the deposition of amyloid-b and the amyloid cascade hypothesis.”
“The study on 60 aged human brains identified a number of relationships between the degree of severity of amyloid-b neuropathology and the metal content of tissue from the donor brains. The latter was recently published for aluminium, copper and iron (House et al. (2012) Metallomics 4, 56-65).


Relationships, PLURAL and severity.

“Specifically, the extent and severity of amyloid-b deposition was inversely related to the copper content of brain tissue. Lower copper resulted in more severe and more extensive deposition of amyloid-b in the donor brain.”
But obviously you’re crazy to read about it.
“The research suggested that for those individuals with moderate to severe amyloid pathology, a copper to aluminium ratio of less than 20 predicted dementia.”
“Professor Exley said: “The hypothesis requires further testing but if proven correct it could explain why some individuals with senile plaques do not suffer from dementia. The implication being that a high brain tissue ratio of copper to aluminium protects against neurotoxicity associated with the deposition of amyloid-b and the amyloid cascade hypothesis.””

https://www.sciencedirect.com/science/article/pii/S0162013411002145
Aluminium-specific chelators reduce symptoms. Coincidence?
https://www.sciencedirect.com/science/article/pii/S0161813X1530036X
Effect is seen with low levels too:
https://www.sciencedirect.com/science/article/pii/S0161813X1530036X
By this means, the body burden of aluminum in humans has increased. Epidemiological and experimental findings indicate that aluminum is not as harmless as was previously thought, and that aluminum may contribute to the inception and advancement of Alzheimer’s disease. Epidemiological data is reinforced by indications that aluminum exposure can result in excess inflammatory activity within the brain.


“Evidence is presented that reinforces the likelihood that aluminum is a factor speeding the rate of brain aging. Such acceleration would inevitably enlarge the incidence of age-related neurological diseases.”

Maybe most Baby Boomers would be okay if their brains weren’t poisoned?

https://www.sciencedirect.com/science/article/pii/S0301008210000936
“However, disruption of these mechanisms, or absorption of detrimental metals with no known biological function, alter the ionic balance and can result in a disease state, including several neurodegenerative disorders such as Alzheimer’s disease. Understanding the complex structural and functional interactions of metal ions with the various intracellular and extracellular components of the central nervous system, under normal conditions and during neurodegeneration, is essential for the development of effective therapies.”

I hope you plan on someone in Big Pharma coming to kill you for developing therapies.

https://www.sciencedirect.com/science/article/pii/B9780444508119500471
http://orthomolecular.org/library/jom/2000/articles/2000-v15n01-p021.shtml
Opening line: “Aluminum has been identified as a neurotoxin for over 100 years.”
As safe as lead or mercury.

http://www.alz-disease.org/downloads/Aluminum2.pdf
You know where the society said no studies?
“A 2008 systematic review of studies that included aluminum exposure through drinking water, diet, and occupation found 23 studies demonstrated an increased risk for Alzheimer’s disease with elevated aluminum exposure, 3 found that there was no connection…”
Cover-up? Where’s the science?

I can’t seem to find it, guys!

https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-016-0342-y
We screened 4784 studies and included 60 in the review. Risk factors were considered in six categories: air quality, toxic heavy metals, other metals, other trace elements, occupational-related exposures, and miscellaneous environmental factors. Few studies took a life course approach. There is at least moderate evidence implicating the following risk factors: air pollution; aluminium; silicon; selenium; pesticides; vitamin D deficiency; and electric and magnetic fields.”
Life course is ideal.

https://www.aerzteblatt.de/int/archive/article/193516
There is a threshold.
“Our article examines the question of whether environmental and therapeutic aluminum exposure increases the risk of disease. To this end, Alzheimer’s disease and breast cancer are taken as critical endpoints. Aluminum’s neurotoxic effects in humans and its embryotoxic effects in animal models have been proven (4).”

https://www.futsci.com/uploads/project/file/f004582d987d2142ba418d26149d258d64e024e9.pdf
“An inevitable consequence of humans living in
the Aluminium Age is the presence of aluminium in the
brain. This non-essential, neurotoxic metal gains entry to
the brain throughout all stages of human development,
from the foetus through to old age. Human exposure to
myriad forms of this ubiquitous and omnipresent metal
makes its presence in the brain inevitable, while the
structure and physiology of the brain makes it particularly
susceptible to the accumulation of aluminium with age. In
spite of aluminium’s complete lack of biological essentiality,
it actually participates avidly in brain biochemistry
and substitutes for essential metals in critical biochemical
processes. The degree to which such substitutions are disruptive
and are manifested as biological effects will depend
upon the biological availability of aluminium in any particular
physical or chemical compartment, and will under
all circumstances be exerting an energy load on the brain.
In short, the brain must expend energy in its ‘unconscious’
response to an exposure to biologically available aluminium.
There are many examples where ‘biological effect’
has resulted in aluminium-induced neurotoxicity and most
potently in conditions that have resulted in an aluminiumassociated
encephalopathy. However, since aluminium is
non-essential and not required by the brain, its biological
availability will only rarely achieve such levels of acuity,
and it is more pertinent to consider and investigate the
brain’s response to much lower though sustained levels of
biologically reactive aluminium. This is the level of
exposure that defines the putative role of aluminium in
chronic neurodegenerative disease and, though thoroughly
investigated in numerous animal models, the chronic toxicity
of aluminium has yet to be addressed experimentally
in humans. A feasible test of the ‘aluminium hypothesis’,
whereby aluminium in the human brain is implicated in
chronic neurodegenerative disease, would be to reduce the
brain’s aluminium load to the lowest possible level by noninvasive
means. The simplest way that this aim can be
fulfilled in a significant and relevant population is by
facilitating the urinary excretion of aluminium through the
regular drinking of a silicic acid-rich mineral water over an
extended time period. This will lower the body and
brain burden of aluminium, and by doing so will test
whether brain aluminium contributes significantly to
chronic neurodegenerative diseases such as Alzheimer’s
and Parkinson’s.”

Of course, A Drink is cheaper than all the care of the sick patients and you can’t steal their house legally by telling the council they lack competence.

“Certainly aluminium either directly as a
particulate or indirectly following the dissolution of
nanoparticulates could induce an inflammatory action in
the human brain, and this has been demonstrated in animal
models [64]. The immunopotency of aluminiumbased
adjuvants outside their role as adjuvants in vaccine
and allergy therapies seems to have been largely ignored
as a potential mechanism of aluminium toxicity
throughout the body [65] and especially in the nervous
system [66]. The consistent observation of significant
accumulations of aluminium in the brain should at least
be a warning of the potential for such to participate in
neuroinflammatory toxicity.”

You’d think.

The brain is an obvious target for aluminium toxicity.
Neurotoxicity is evident under acute conditions such as
encephalopathies, and it is predicted but not necessarily
recognised as such under chronic or everyday exposures to
environmental aluminium. The mechanisms of neurotoxicity
are potentially myriad, while their manifestations as
biochemical changes are probably quite subtle for all but
the most vulnerable groups.”

Headaches, stomach aches, etc. “Brain fog” might be entirely toxin based.

“While the latter must include
the foetus and neonate, there are few indications as to the
identities of others who are susceptible to the neurotoxicity
of aluminium. Since the advent of the Hall-He´roult process
(and thereafter Bayer process) towards the end of the
nineteenth century and our ability to extract aluminium
from its inert ores on an industrial scale, we have all been
living in the Aluminium Age [67]. Now, in the twenty-first
century, we can no longer completely avoid environmental
exposure to aluminium. Since there is as yet no proven
requirement for aluminium in any living organism, never
mind in humans, it would be prudent to reduce our
everyday exposure to avoid aluminium entering the body
and persisting in the human brain [68].”

It’s used to process junk food, watch How It’s Made.
When people feel better after giving up junk, it might be aluminium exposure reduction.

It would be easy to study: people who eat a lot of junk and people who don’t, Al urine amounts.

“We have begun to
show that this can be achieved by using nature’s own way
of avoiding biologically available aluminium. We have
shown that regular consumption of silicon-rich mineral
waters both reduce our gastrointestinal uptake of aluminium
and, importantly, facilitate our urinary excretion of
systemic aluminium [48]. Life on Earth evolved in spite of
a crust of aluminosilicate [1]. However, the Hall-He´roult
process and the subsequent arrival of an Aluminium Age
have let the aluminium genie out of the bottle. Our final
wish should be that the unique inorganic chemistry of
aluminium and silicic acid will help to put the genie back
where it can be used effectively but, most importantly,
safely.”

Trans. We evolved to take silicon into our brain but aluminium is taking its place.
It lied on its CV, it needs to be fired.

http://www.academia.edu/12143618/Aluminium_and_Alzheimer_s_Disease_A_Suspicious_Link
“This article summarizes the various ways in which Al induces oxidative stress, eventually leading to cell death. It also gives a brief account of manifold epidemiological studies that relate the abundant occurrence of Al in soil and water and the prevalence of AD. Al carriers, their role in AD, Al in neurofibrillary tangles, biochemical reactions altered by Al influx in mitochondria have been briefly discussed.”
One of the key words is apoptosis…

https://lib.dr.iastate.edu/cgi/viewcontent.cgi?referer=https://www.bing.com/&httpsredir=1&article=11467&context=rtd
https://www.researchgate.net/publication/21666142_Aluminium_accumulation_beta-amyloid_deposition_and_neurofibrillary_changes_in_the_central_nervous_system
“If aluminium contributes to the development of sporadic AD, it must do so indirectly, perhaps via effects on the synthesis or metabolism of APP, or by contributing generally to the age-related attrition of neurons and thus reducing the threshold for deficits produced by more specific disease-related processes.”

Final study describes a mechanism.

https://core.ac.uk/download/pdf/81923975.pdf
Back-up PDFs are always useful.

https://www.tandfonline.com/doi/abs/10.3109/07853898909149192?journalCode=iann20

https://www.deepdyve.com/lp/elsevier/demonstration-of-aluminum-in-amyloid-fibers-in-the-cores-of-senile-cwa8nRkSAh

https://febs.onlinelibrary.wiley.com/doi/full/10.1016/j.febslet.2006.10.075
Active effect of aluminium on the brain’s self-cleaning.

https://www.frontiersin.org/articles/10.3389/fneur.2014.00167/full
“Aluminum, as an extremely high charge density cation (Z2/r = 18), has the remarkable capability to both (1) aggregate and compact Aβ42 peptide monomers into higher order, more neurotoxic oligomeric, and fibrillar structures, and (2) impair, at the molecular-genetic* level, the cellular machinery responsible for Aβ42 peptide monomer phagocytosis and clearance from the cell (4–13).”

*Hints at genetic damage.

Apparently the levels we ingest are “physiologically realistic.” As in, it can affect you.

They need chelation therapy.

SSRIs are anger management pills

http://www.pnas.org/content/94/11/5939.full

The amine serotonin [5-hydroxytryptamine creatinine sulfate complex (5HT)] has been linked to aggression in a wide and diverse range of species, including humans (1720). The nature of the linkage, however, is not simple, and it has proven difficult to unravel the role of the amine in the behavior. In vertebrates, lowered levels of 5HT (endogenous or experimentally induced) or changes in amine neuron function that lower the effectiveness of serotonergic neurons generally correlate with increased levels of aggression (1920) whereas in invertebrates, the converse is believed to be true (1113). Genetic alterations of amine neuron function also can change aggressive behavior in animals (2124) and in people (2527) although, again, in most cases, it is not clear how the genetic change is linked to the behavior. For example, in humans, a mutation leading to inactivation of one form of the enzyme monoamine oxidase leads to a particular form of explosive violent behavior (2627). Because this enzyme is believed to be involved in further metabolism or inactivation of amines, this defect should result in elevated levels of amines, as has been seen in a knockout mutation of the monoamine oxidase enzyme in mice (21). The behavioral manifestation, however, is that generally thought to be associated with lowered levels of 5HT. Finally, direct injections of amines like 5HT into animals also cause changes in aggression, but even here the relationships are complex. For example, in ants, injections of 5HT and its precursors lower interspecific aggressiveness toward intruders but raises intraspecies aggression (2829).

They don’t help with “most people”

https://www.spring.org.uk/2008/02/new-study-ssri-antidepressants-dont.php

A new study published today is sure to set off another storm in the ongoing debate about the widespread prescription of antidepressants. Professor Irving Kirsch at the University of Hull and colleagues in the US and Canada report that new generation ‘SSRI’ antidepressants like Prozac or Seroxat mostly fall, “below the recommended criteria for clinical significance” (Kirsch et al. 2008). In other words, the most modern drugs prescribed for depression generally don’t work.

 The study was particularly interested in whether the drugs had different effects on people with different levels of depression. Here is what they found:
  • Mild depression: not tested as mild depression is usually treated with a ‘talk therapy’ rather than antidepressants.
  • Moderate depression: antidepressants made “virtually no difference”.
  • Severe depression: antidepressants had a “small and clinically insignificant” effect.
  • Most severe depression: antidepressants had a significant clinical benefit – but see below…

https://www.sciencedirect.com/science/article/pii/S0014299905009817

Antidepressant treatments and human aggression

We need more studies on that.

Aggressive behaviour is associated with negative mood and poor impulse control. Serotonin has been specifically associated with impulse regulation and deficiencies in serotonin have been linked to impulsive aggression.

Or they could learn impulse control, like previous generations.

However, aggression occurs in a social context and noradrenaline has been implicated in social motivation. Both serotonergic and noradrenergic antidepressants may therefore be effective in reducing aggression. The evidence for the effects of antidepressants on aggression comes from a wide range of sources but there are few controlled trials or experimental studies. Current findings point to decreases in negative mood and anger attacks and positive changes in personality traits after antidepressant treatment.

fake changes

never letting them suffer, learn, grow and improve

no character development whatsoever

forced immaturity

Clinical studies in personality disorder patients have shown some efficacy for serotonergic antidepressants in reducing irritability and impulsive aggression. Experimental work in healthy volunteers has shown both serotonergic and noradrenergic antidepressants to increase assertiveness and affiliative behaviour. Both may therefore decrease aggression through different routes.

Not the same thing.

Asking your boss for a raise is different than threatening him if he doesn’t.

http://www.dana.org/Publications/Brainwork/Details.aspx?id=43750

Now, researchers at Cambridge University and UCLA have found that serotonin also plays a critical role in regulating emotions such as impulsive aggression during social decision making.

SSRI patients are still making self-destructive life choices.
It’s a band aid on a broken leg!

Impulsive aggression is the tendency to respond with hostility or aggression when faced with serious frustration.

character flaw

The researchers believe their results suggest that serotonin plays a critical role in social decision making by normally keeping aggressive social responses in check.

See: angry vegans.

Under normal circumstances, serotonin works in the frontal areas of the brain to inhibit the firing of the amygdala, the almond-shaped structure that controls fear, anger and other emotional responses.

*sarcastic clapping*

Wonder why so many of my generation are cunts?

The anger is their real personality, suppressed by the drug.

I say this from compassion, because in the eventual situation where the supply chain is interrupted for a few weeks, they’ll kill themselves in a fit of pique. (Directly or by picking fights).

Why aren’t men fighting for the West?

They’re drugging themselves with male victory soma – steroids.
If they feel the complacency (and entitlement) of the victor, why bother?

(The testosterone released by compulsive masturbators has the same effect, teenage boys used to have more motivation when it was discouraged, SJWs noticed).

https://link.springer.com/chapter/10.1007%2F978-3-319-02904-7_12

Testosterone is the dominant hormone in both male and female brains.

regulates the turnover of the social monoamines, dopamine and serotonin.

They’re happy pills, indirect happy pills.
For people too proud to admit they’re depressed.

The hormone also has many other actions in the brain; thus the social brain’s main chemical, without exaggeration, is testosterone

Peterson told you none of this.

 investigate social dominance and trustworthiness behaviors

Whatever I say, they’ll insult me.

Losers.

….

Actually, why do I care what they think? Who else does?

Fine. If you need to get energy from drugs, and don’t see that as a problem to be dropped at some point, you’re as bad a degenerate as the people you insult. Why do you think they’re doing it??

(Also: why r-types do drugs. There’s nothing intellectual about it. To avoid negative consequences, they get high or drunk or laid again, to avoid the experience’s outcome and the need to learn from it).

Guardian test, they’re doing it. For the “energy” = narc supply.

https://www.theguardian.com/society/2017/mar/31/rise-in-middle-aged-men-taking-steroids-to-feel-more-youthful-experts-say

But women don’t care about looks, huh….. keep telling yourself that.

At best, you’re the Beautiful Ones. Still unfit and not masculine.

https://www.ncbi.nlm.nih.gov/pubmed/9624002?dopt=Abstract

Studies in animals have implicated the amygdala in emotional and social behaviours, especially those related to fear and aggression. Although lesion and functional imaging studies in humans have demonstrated the amygdala’s participation in recognizing emotional facial expressions, its role in human social behaviour has remained unclear. We report here our investigation into the hypothesis that the human amygdala is required for accurate social judgments of other individuals on the basis of their facial appearance. We asked three subjects with complete bilateral amygdala damage to judge faces of unfamiliar people with respect to two attributes important in real-life social encounters: approachability and trustworthiness. All three subjects judged unfamiliar individuals to be more approachable and more trustworthy than did control subjects.The impairment was most striking for faces to which normal subjects assign the most negative ratings: unapproachable and untrustworthy looking individuals. Additional investigations revealed that the impairment does not extend to judging verbal descriptions of people. The amygdala appears to be an important component of the neural systems that help retrieve socially relevant knowledge on the basis of facial appearance.

r-types

https://www.ncbi.nlm.nih.gov/pubmed/12948440

Basolateral amygdala and orbitofrontal cortex are implicated in cue-outcome learning. In this issue of Neuron, Schoenbaum et al. show that, following basolateral amygdala lesions, cue-selective neurons in orbitofrontal cortex are more sensory driven and less sensitive to the motivational value of an outcome, suggesting that predictive value coding in orbitofrontal cortex is dependent on input from basolateral amygdala.

They’re conditioning themselves for pathological altruism.

https://disenchantedscholar.wordpress.com/2018/05/06/why-does-shunning-make-locusts-leave/

By making your brain happy, you make it dumber.

It’s the illusion of safety. Your body assumes the threat is dead.

Your body also produces less of a thing when you supplement. Basic biology.
So men and women shouldn’t take any sex hormones unless they produce zero.

If your levels are normal (for your AGE, Peter Pan), you’re poisoning yourself.

https://www.nature.com/scitable/blog/cognoculture/testosterone_and_human_aggression_or_180520

 Yet others still have suggested that hypogonadal males (a.k.a low testosterone-producing males) who had their testosterone increased saw no jump in aggressive behaviour, and in fact became more friendly, energetic and, well, happy.

Cucks.

If you’re being treated badly, the chemical suffering is vital to fixing that. It’s like cutting off nerves, they’ve deadened their sense of injustice.

Notice how when men get power, they become over-friendly and obliging?

Ah, they say, but wouldn’t this also occur in women?

 The result: the women who had received testosterone without knowing became fairer, more generous and had increased efficiency in social interactions, while the other group (those who had been told that they were receiving testosterone) behaved much more unfairly. In sum: one group acted they way they thought testosterone should affect humans (and it wasn’t pretty). But the reality was much different. Case and point, ladies and gentlemen.

Notice how many pathological altruist women are high-T? And middle-class?

You’re buying the chemical fake equivalent of class. I cannot think of anything more indicative of a loser.

I used to think it was the broke guy with a sportscar.

If anyone’s doping T, it should be women. It makes us nicer and better looking. When we produce less naturally, no loss.

It’s always the “inferior” men who abuse women, isn’t it? They seem to be lacking in T.
In civilization, status is conferred to men who cooperate. Killers get wiped out quickly.

The neurotoxin aluminium

Paper dump for SEO, a solid starting point.

http://www.drpepi.com/aluminum-poisoning.php
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056430/
Anecdotal but observational science: Baby Boomers have record Alzheimer’s rates. Boomers are also the first generation raised with aluminium, as “safer” than tin.
…It’s also cheaper.

https://www.ncbi.nlm.nih.gov/pubmed/27455809

A lot of restaurants don’t want to get sued (cosmetics companies neither).
The claims of papers like these, widely/falsely cited as ‘debunking’, don’t hold up to a basic level of biological knowledge. They are critical of a hypothesis for theoretical reasons they do not actively study, so it is not the all-clear being claimed by the intellectually dishonest, which would require actually testing them in a longitudinal experimental study (medical field standard). This is particularly important as any method design with heavy metals, which build up in the body (forming compounds together, in a cocktail effect) over decades. Rat studies go one-by-one, an element at a time, which lacks external validity/ real-world relevance.

https://www.ncbi.nlm.nih.gov/pubmed/21157018
1. the blood-brain barrier thins with age. This is a fact.
2. Aluminium can combine with other elements e.g. fluoride, to form a compound which might pass the barrier where healthy and young.
If you look at what’s literally IN the brain tissue of dead patients?
http://science.sciencemag.org/content/180/4085/511
Aluminium.

Respectfully, to the critics:

How the hell did it get there?

There’s your smoking gun, your bloodied Macbeth hands.

That is rock solid, irrefutable proof. As it stands, here is more proof.
Evidence for point 2: http://www.tandfonline.com/doi/abs/10.1080/10611860400015936
Known since at least 1998: http://www.actionpa.org/fluoride/aluminum.html
EU drinking/cooking water may contain arsenic, which explains a lot:
https://ec.europa.eu/health/scientific_committees/opinions_layman/fluoridation/en/l-3/2.htm
http://www.sciencedirect.com/science/article/pii/S0278691504000365

This is like the talc-cancer thing that recently came out in all the lawsuits.
I don’t have to explain that to you, do I?