SSRIs are anger management pills

http://www.pnas.org/content/94/11/5939.full

The amine serotonin [5-hydroxytryptamine creatinine sulfate complex (5HT)] has been linked to aggression in a wide and diverse range of species, including humans (1720). The nature of the linkage, however, is not simple, and it has proven difficult to unravel the role of the amine in the behavior. In vertebrates, lowered levels of 5HT (endogenous or experimentally induced) or changes in amine neuron function that lower the effectiveness of serotonergic neurons generally correlate with increased levels of aggression (1920) whereas in invertebrates, the converse is believed to be true (1113). Genetic alterations of amine neuron function also can change aggressive behavior in animals (2124) and in people (2527) although, again, in most cases, it is not clear how the genetic change is linked to the behavior. For example, in humans, a mutation leading to inactivation of one form of the enzyme monoamine oxidase leads to a particular form of explosive violent behavior (2627). Because this enzyme is believed to be involved in further metabolism or inactivation of amines, this defect should result in elevated levels of amines, as has been seen in a knockout mutation of the monoamine oxidase enzyme in mice (21). The behavioral manifestation, however, is that generally thought to be associated with lowered levels of 5HT. Finally, direct injections of amines like 5HT into animals also cause changes in aggression, but even here the relationships are complex. For example, in ants, injections of 5HT and its precursors lower interspecific aggressiveness toward intruders but raises intraspecies aggression (2829).

They don’t help with “most people”

https://www.spring.org.uk/2008/02/new-study-ssri-antidepressants-dont.php

A new study published today is sure to set off another storm in the ongoing debate about the widespread prescription of antidepressants. Professor Irving Kirsch at the University of Hull and colleagues in the US and Canada report that new generation ‘SSRI’ antidepressants like Prozac or Seroxat mostly fall, “below the recommended criteria for clinical significance” (Kirsch et al. 2008). In other words, the most modern drugs prescribed for depression generally don’t work.

 The study was particularly interested in whether the drugs had different effects on people with different levels of depression. Here is what they found:
  • Mild depression: not tested as mild depression is usually treated with a ‘talk therapy’ rather than antidepressants.
  • Moderate depression: antidepressants made “virtually no difference”.
  • Severe depression: antidepressants had a “small and clinically insignificant” effect.
  • Most severe depression: antidepressants had a significant clinical benefit – but see below…

https://www.sciencedirect.com/science/article/pii/S0014299905009817

Antidepressant treatments and human aggression

We need more studies on that.

Aggressive behaviour is associated with negative mood and poor impulse control. Serotonin has been specifically associated with impulse regulation and deficiencies in serotonin have been linked to impulsive aggression.

Or they could learn impulse control, like previous generations.

However, aggression occurs in a social context and noradrenaline has been implicated in social motivation. Both serotonergic and noradrenergic antidepressants may therefore be effective in reducing aggression. The evidence for the effects of antidepressants on aggression comes from a wide range of sources but there are few controlled trials or experimental studies. Current findings point to decreases in negative mood and anger attacks and positive changes in personality traits after antidepressant treatment.

fake changes

never letting them suffer, learn, grow and improve

no character development whatsoever

forced immaturity

Clinical studies in personality disorder patients have shown some efficacy for serotonergic antidepressants in reducing irritability and impulsive aggression. Experimental work in healthy volunteers has shown both serotonergic and noradrenergic antidepressants to increase assertiveness and affiliative behaviour. Both may therefore decrease aggression through different routes.

Not the same thing.

Asking your boss for a raise is different than threatening him if he doesn’t.

http://www.dana.org/Publications/Brainwork/Details.aspx?id=43750

Now, researchers at Cambridge University and UCLA have found that serotonin also plays a critical role in regulating emotions such as impulsive aggression during social decision making.

SSRI patients are still making self-destructive life choices.
It’s a band aid on a broken leg!

Impulsive aggression is the tendency to respond with hostility or aggression when faced with serious frustration.

character flaw

The researchers believe their results suggest that serotonin plays a critical role in social decision making by normally keeping aggressive social responses in check.

See: angry vegans.

Under normal circumstances, serotonin works in the frontal areas of the brain to inhibit the firing of the amygdala, the almond-shaped structure that controls fear, anger and other emotional responses.

*sarcastic clapping*

Wonder why so many of my generation are cunts?

The anger is their real personality, suppressed by the drug.

I say this from compassion, because in the eventual situation where the supply chain is interrupted for a few weeks, they’ll kill themselves in a fit of pique. (Directly or by picking fights).

Drugs and homicide

All this hullabaloo about that Panorama documentary, I must throw my hat in the ring.

It’s an expensive hat, don’t touch it.

BRIEFLY

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471985/

Quantitative data from the U.S. Food and Drug Administration (FDA) adverse event reporting system (7) imply that some antidepressants may be associated with a disproportionately high number of violent events (8).

so it is an issue, just not with the entire class

Duh.

That’s a strawman.

Find me one recent spree killer who wasn’t on these meds at some point.
Now look up the fact that brain changes are permanent.

http://articles.mercola.com/sites/articles/archive/2001/08/04/serotonin-part-one.aspx

You’re not supposed to take them unless you’re actually depressed.

The overdiagnosis problem is not a matter of theory, it’s a question of brain-damaging people with the blues.

And they don’t actually prevent suicide if you look at outcomes.
By rigging the chemistry, they can actually make it likelier, since the brain tries to compensate for the drugs.

http://www.telegraph.co.uk/news/2016/10/12/rows-over-study-which-claims-antidepressants-double-suicide-risk/

Researchers behind the Danish review said the study demolished “potentially lethal misconceptions” about the safety of the drugs, which are taken by more than 4 million Britons a year.

The analysis examined 13 studies, to see what impact the drugs had on patients who did not suffer from depression.

Scientists said these patients were selected, because previous studies linking suicide and antidepressants had been dismissed by those who said the deaths must have been caused by the mental health condition, rather than the pills.

…Prof Peter Gotzsche, of the Nordic Cochrane Centre, said such feelings could be considered as “precursors to suicidality or violence”

I suggest there’s a difference in effect on men and women.
This would explain the male suicide rate and homicide risk.

https://www.cchrint.org/2014/04/24/ssri-antidepressants-the-gateway-drug-to-mass-murder/

drawing specific attention to a number of mass shootings that have occurred as a result of these drugs. Prozac, for instance, which is often prescribed for attention deficit hyperactivity disorder (ADHD), was responsible for triggering multiple mass shootings at schools during the 1990s and 2000s, while other SSRIs have been linked to similar shootings.

http://www.naturalnews.com/039752_mass_shootings_psychiatric_drugs_antidepressants.html

Every mass shooting over last 20 years has one thing in common… and it’s not guns

https://ssristories.org/category/cause-of-death/murder-suicide/

From the homepage

There is a U.K. organization called Hundredfamilies  (http://www.hundredfamilies.org/ ).  It is concerned about homicides committed by people who are mentally ill, and wants the government to do more to prevent these deaths….

Naturally this gets covered up because ‘stigma’.

Ignore the people trying to abuse and rape and murder you! That sounds fine!

Prozac can lead to suicide and cause aggression, at least. This is well-known in the field.

Anti-psychotics are the worst though, the strongest meds.

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(05)73526-1/abstract

It’s almost like the brain is a complex organ and you shouldn’t fuck with it.

The serotonin imbalance hypothesis of depression wasn’t even right. It’s been shown as completely wrong – and you can have excess serotonin problems too. There’s no evidence in humans for serotonin deficiency, and even then, most serotonin is produced in the gut so it’s really a microbiome issue. #biology101 Naturally, insurance doesn’t pay as much for that as psychiatric meds.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165625/

In the studies where violence goes down?

Funding

The Wellcome Trust

http://www.medscape.com/viewarticle/846302

Psychotropic medications, including antidepressants, benzodiazepines, and particularly opiate and nonopiate analgesics, are associated with a significantly increased risk for homicide, new research shows.

Jari Tiihonen, MD, PhD, professor, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, and colleagues found that antidepressants increase the homicide risk by 31% and that benzodiazepines increase the risk by 45%.

https://www.ncbi.nlm.nih.gov/pubmed/26372359

CONCLUSIONS:

The association between SSRIs and violent crime convictions and violent crime arrests varied by age group. The increased risk we found in young people needs validation in other studies.

ageism!

https://www.ncbi.nlm.nih.gov/pubmed/20004282

There is an association of homicide with mental disorder, most particularly with certain manifestations of schizophrenia, antisocial personality disorder and drug or alcohol abuse. However, it is not clear why some patients behave violently and others do not. Studies of people convicted of homicide have used different definitions of mental disorder…..

Mental disease is the original non-PC term for ‘mental illness’.
TBF NAKALT… wait….

According to the definition of Hodgins, only 15% of murderers have a major mental disorder (schizophrenia, paranoia, melancholia).

Mental disorder increases the risk of homicidal violence by two-fold in men and six-fold in women.

Schizophrenia increases the risk of violence by six to 10-fold in men and eight to 10-fold in women.

Click to access kauffman2009.pdf

WHEN IN DOUBT, RESEARCH.

THERE IS DOUBT.

nobody has any reason to say You Shouldn’t Research That

those people are anti-science

SSRIs reportedly interact with 40 other drugs to cause
“serotonin syndrome.” This presents as twitching, tremors, rigidity,
fever, confusion, or agitation. Serotonin/norepinephrine reuptake
inhibitors (SNRIs) also may cause serotonin syndrome by
interactions

Excess serotonin.
Like I said the other day, a lot of these ‘depressed’ SJWs are causing their own ‘anxiety’ symptoms by dosing on the SSRIs instead of changing their life.

Just a year after fluoxetine was introduced, Bill Forsyth of
Maui, Hawaii, had taken it for only 12 days when he committed one
of the first murder/suicides attributed to any SSRI. In the same year
Joseph Wesbecker killed eight others and himself in a Louisville,
Ky., printing plant where he worked, after 4 weeks on fluoxetine.
Yet as early as 1986, clinical trials showed a rate of 12.5 suicides per
1,000 subjects on fluoxetine vs. 3.8 on older non-SSRIs vs. 2.5 on
placebo!An internal 1985 Lilly document found even worse results
and said that benefits were less than risks. Such documents were
released into the public domain by Lilly as part of the settlement in
the Wesbecker case. Fifteen more “anecdotes” of murder/suicide,
three with sertraline, were listed by DeGrandpre

This link has been known since the 80s

and we’re only discussing it now.

But trust Big Pharma.

Serotonin mediates decision-making and affects arousal response (anger)

Study 1: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504725/

People with higher (normal) levels were played for suckers in a negotiation game, trusting and took plenty of offers, good and bad. It’s like they were doped happy and were easygoing about the result. People with lower levels (associated in drinking with recklessness, possible violence and increased libido) were strategic, patient and took the good offers (for in-game resources). It suggests an effect on planning and time preference.

Study 2: http://www.cam.ac.uk/research/news/serotonin-levels-affect-the-brain%E2%80%99s-response-to-anger

For the study, healthy volunteers’ serotonin levels were altered by manipulating their diet.

The preppers are right about the psychological implications of mild to moderate starvation. If it doesn’t affect you, it’ll seem unpredictable in those around you. Granny will knife you for a tin of beans. This is the brain’s natural state, modern 21st century fat and happy is bread and circuses.

The research revealed that low brain serotonin made communications between specific brain regions of the emotional limbic system of the brain (a structure called the amygdala) and the frontal lobes weaker compared to those present under normal levels of serotonin. The findings suggest that when serotonin levels are low, it may be more difficult for the prefrontal cortex to control emotional responses to anger that are generated within the amygdala.

Logic switches off. You get roid rage.

Using a personality questionnaire, they also determined which individuals have a natural tendency to behave aggressively. In these individuals, the communications between the amygdala and the prefrontal cortex was even weaker following serotonin depletion.

This might explain what’s happening to the K-types in Europe.

“Although these results came from healthy volunteers, they are also relevant for a broad range of psychiatric disorders in which violence is a common problem. For example, these results may help to explain the brain mechanisms of a psychiatric disorder known as intermittent explosive disorder (IED). Individuals with IED typically show intense, extreme and uncontrollable outbursts of violence which may be triggered by cues of provocation such as a facial expression of anger.

The usual suspects, fat and happy ‘victim groups’ causing trouble, rioting and protesting, are in for quite a shock if they keep pushing it. It makes you happier to commit violence, but a lesser known effect is it alters the memory patterns of PTSD affecting formation and recovery. This is genetic.

http://www.sciencedaily.com/releases/2010/06/100617102712.htm

…This same gene variant increases the activation of an emotion control center in the brain, the amygdala…..

Feeling emasculated leads to violence: http://psychcentral.com/news/2015/08/26/perception-of-low-masculinity-may-lead-to-violence/91374.html but by all means, continue to scream in the native’s faces.

Why do I link these?

Well, I believe the reason for r/K shifts is the serotonin functioning within the amygdala. If the gut-brain axis can be affected in it by everything from neonatal levels (that can cause SIDS or on the other end, boost learning ability) to child abuse (yep, the stress of it can cause adult health issues via serotonin), then a local effect on the brain is easily understood. This ties into the fact many people are on SSRIs despite recent findings saying that as many as 2/3 of people on antidepressants don’t need them (for depression, which they don’t have). It could be self-medication for seeing the world as it is (depressives have the most realistic perception) and relate to subtle suicide, a pattern of self-destructiveness that ties in well to recent ‘culture’: http://blogs.psychcentral.com/nlp/2015/11/subtle-suicide/ by smoking, drinking, eating too much (and presumably, recklessly sleeping around, risking HIV and cancers).

SSRIs can be given as treatment for self-proclaimed ‘anxiety’ (many feminists are on them) but take a look at the symptoms of too much;

Mild symptoms may consist of increased heart rate, shivering, sweating, dilated pupils, myoclonus (intermittent jerking or twitching), as well as overresponsive reflexes.

Yeah, the anxiety drugs might be giving them the symptoms OF anxiety.

oh no oh dear hides facepalm double

mfw

P.S. ‘Social anxiety’ aka being a pussy and refusing to learn the rules, is related to high serotonin: http://articles.mercola.com/sites/articles/archive/2015/07/02/social-anxiety-disorder.aspx

At best, antidepressants are comparable to placebos. At worst they can cause devastating side effects, including deterioration into more serious mental illness, and suicidal or homicidal tendencies.

I love how flippantly they write this. Sure, hand them out like candy.

Virtually all of the school and mass shooters, for example, have been on antidepressants. Antidepressants are also prescribed to pregnant women, which can have serious repercussions for the child.

yup damon ian somerhalder vampire diaries hot duh yes uhuh

Those with social anxiety? They’re too comfortable.

Previous studies have revealed that increased nerve activity in the amygdala is part of the underlying mechanism that produces anxiety. Basically, those with social phobia have an over-active fear center. These new findings provide additional information, suggesting increased serotonin production in the brain may be part of this mechanism.

*swears in your general direction*

…Pussies. They’re anxious about unimportant, regular stimuli (contrary to Study 1). Rejection is a fact of life. Yes, you will be awkward, sometimes. Get over it.
Also, feminists with this need to lay off the sweets and carbs.

Dramatically decrease your consumption of processed foods, sugar (particularly fructose), grains, and GMOs…….

Back to depression.

Most people have heard of the “chemical imbalance” theory, which states that depression and anxiety disorders are due to low serotonin levels. Most believe this theory to be true. But the theory was just that—a theory. It sounds scientific, but there was actually no hard evidence behind it.

At that time, they concluded there was no evidence that there is anything wrong in the serotonergic system of depressed patients.

K-types – if you hate the world, you’re right. It sucks to be young in this era.

SSRIs: A Lengthy Critique

http://slatestarcodex.com/2014/07/07/ssris-much-more-than-you-wanted-to-know/

There was never much more evidence for the serotonin hypothesis than that chemicals that increased serotonin tended to treat depression – making the argument that “antidepressants are biochemically justified because they treat the low serotonin that is causing your depression” kind of circular. Saying “Serotonin treats depression, therefore depression is, at root, a serotonin deficiency” is about as scientifically grounded as saying “Playing with puppies makes depressed people feel better, therefore depression is, at root, a puppy deficiency”.

http://slatestarcodex.com/2015/08/31/magic-markers/ begins;

There’s an old philosophers’ saying – trust those who seek the truth, distrust those who say they’ve found it. The psychiatry version of this goes “Trust those who seek biological underpinnings for mental illness, distrust those who say they’ve found them.”

I covered my own filthy casual opinion here.

The Depressive Personality and why the drugs don’t work (SSRIs)

http://charltonteaching.blogspot.co.uk/2015/06/modern-depression-and-bipolar-disorder.html

It becomes a handy excuse too.

Pop the pills, blame your condition for your failures….

Yes, that’s right.
It even has a clinical term I’m surprised Bruce Charlton doesn’t know/mention: the absolution of responsibility.
It used to be applied to the clinician, a duty of care, but increasingly it is discussed among overdiagnosis (a tragedy of the commons with prescriptions) issues and whether “patients” are embellishing or lying for instrumental gain (welfare, sympathy, an excuse to be a worthless piece of…. I digress).

Most would be better off with placebo pills, as TLP knows (where is she, anyone?). For example, they enjoy the idea they’re broken (hipsters) and hence nothing in/about their life is their fault (ignore the non-sequitur, I know). There is an escalation common in psychiatry, you start on the easy candy stuff like Ritalin and eventually it’s anti-psychotics, with the fun side effect of causing mass murder and shooting sprees you hear about on the news. This is also why feminists wish to drug little boys, it damages them for life and they think it’s revenge for the slutty ones ‘needing’ the Pill. Don’t expect logic.

Drugs should be a last resort, not as casual as an after-dinner mint. A single one begins irreversible changes in the brain. If you weren’t fucked up before, you will be. http://www.medicalnewstoday.com/articles/282784.php

http://www.youtube.com/watch?v=ETxmCCsMoD0

n.b. The chemical imbalance hypothesis is bollocks. Rarely it might apply but there are chemical tests (serotonin for example), as you can probably gather (and CSF, ouch) and those will only get better. It’s an easy theory that sounds scientific but it’s unfalsifiable. Everyone has chemicals. There is no normal pattern either. It’s like choosing introverts or extraverts. Apples and oranges. It ignores genetics and brain structure because Narrative.

How likely is it that a series of disparate imbalances of simple chemicals cause the exact same disorders and conditions as they’re set out purely in the latest DSM-V and ICD-10? It is more likely that I am a bisexual goat.

Take a look: http://www.priory.com/psych/ICD.htm
To this day, those error codes give me a headache.

The (depression) drugs don’t work

http://slatestarcodex.com/2014/07/07/ssris-much-more-than-you-wanted-to-know/

I always make sure to ask a hipster SJW which depression meds she/he is on. Always SSRIs.

Why don’t they work, you ask?
I’m so glad you did. You see, psychology likes to bullshit its way to any plausible sounding causation without doing the Real Science of actually, you know, testing it. Against other explanations. Or beyond correlations. So with the big ($$$) problems like the umbrella ‘depression’ (which now, thanks to lax diagnosis, basically everyone has) there are at least a few Big Causes to be repeated ad nauseum while they can milk it for sweet, sweet funding juice.

Depression pills work on the Chemical Cause hypothesis.
Party line: Mental illness is caused by a neurochemical imbalance in the brain. Note the underline, we’ll come back to it later.

Sure, the brain has neurochemicals. Sure, they can be out of balance (and right themselves again over time, long live control groups). But did you know a normal person taking said pills can have their neurochemistry irreversibly altered? So they require harder and harder ‘medicines’ up to anti-psychotics, the strongest class, taken For Life? Funny that. Also, note the number of spree killers who had a history of this drug escalation in their files. It isn’t gun control laws. It’s the drugs. They don’t work – the way they should. They do work, to worsen already unstable people into psychotic episodes.

If you’re interested in a Berlin psychiatrist’s perspective, this woman is one of my favourite writers.
http://thelastpsychiatrist.com/2008/12/major_depression.html
http://thelastpsychiatrist.com/2008/08/a_solution_to_the_pharma_probl.html
http://thelastpsychiatrist.com/2014/04/the_maintenance_of_certificati.html

Disclaimer: medications have their place IF i) they are thoroughly researched ii) they are correctly applied and iii) they are banned from people who do not demonstrate a need for them (hypochondriacs, drug-abusers and attention-seekers are more common to a psychiatrist than any other type of Doctor).

Why should I care, DS?
Because psychiatry is moving away from relatively harmless SSRIs (if you ignore the Prozac suicides) to the stronger stuff, anti-psychotics. If they can fuck up a schizophrenic, imagine what they can do to normal kids who came in through the door on the blatant BS of ADHD. Expect more shootings, or gorey school stabbings, even if all guns were banned, and other horrific crimes that will be passed off as Religion’s Fault. Did I mention most people brought into London’s prison system, also meet some criteria for schizophrenia? YupThe biology of these medications, and other drugs like ‘safe’ marijuana, are well known. They just don’t care.

To leave you with a brain teaser, consider this addendum to the QM study already cited;

Interestingly, there was no increase in risk of violence for untreated prisoners with delusional disorder. [control group, no drugs] Drug-induced psychosis was linked with a nearly twofold risk of violence following release, but this became non-significant following adjustments for drug and/or alcohol dependence**.

Do you understand more than the researchers now, given this article?